Evidence map›Paper›PMID 34108957›Full record

ArticleFrontiers in immunology2021

A Multi-Omics Analysis of Mucosal-Associated-Invariant T Cells Reveals Key Drivers of Distinct Modes of Activation.

Kristin Schubert, Isabel Karkossa, Jana Schor, Beatrice Engelmann, Lisa Maria Steinheuer, Tony Bruns, Ulrike Rolle-Kampczyk, Jörg Hackermüller, Martin von Bergen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  11. Transcriptomic profile ofFrontiers in immunology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kristin SchubertDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research (UFZ), Leipzig, Germany.
Isabel KarkossaDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research (UFZ), Leipzig, Germany.
Jana SchorDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research (UFZ), Leipzig, Germany.
Beatrice EngelmannDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research (UFZ), Leipzig, Germany.
Lisa Maria SteinheuerDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research (UFZ), Leipzig, Germany.
Tony BrunsDepartment of Medicine III, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen (RWTH), Aachen, Germany.
Ulrike Rolle-KampczykDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research (UFZ), Leipzig, Germany.
Jörg HackermüllerDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research (UFZ), Leipzig, Germany.
Martin von BergenDepartment of Molecular Systems Biology, Helmholtz-Centre for Environmental Research (UFZ), Leipzig, Germany.
Helmholtz Centre for Environmental Research · DELeipzig University · DERWTH Aachen University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The function of mucosal-associated invariant T (MAIT) cells highly depends on the mode of activation, either by recognition of bacterial metabolites

Indexed as

Gene Expression ProfilingMetabolomicsProteomicsBiomarkersCells, CulturedChromatography, LiquidComputational BiologyHigh-Throughput Nucleotide SequencingHumansImmunophenotypingLymphocyte ActivationMucosal-Associated Invariant T CellsReceptors, Antigen, T-CellTandem Mass SpectrometryBiomarkersReceptors, Antigen, T-Cellactivationkey driver analysisMAIT cellsmulti-omics analysisTCR-dependentTCR-independent

Identifiers

PMID34108957
PMCPMC8183572
OpenAlexW3164002891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.