Evidence map›Paper›PMID 34108940›Full record

ArticleFrontiers in endocrinology2021

Adults' Adherence to Growth Hormone Replacement in Relation to Medication-Related Beliefs, Coping and Quality of Life - An Exploratory Analysis.

Sonja Siegel, Nicole Unger, Christine Streetz-van der Werf, Wolfram Karges, Katharina Schilbach, Bernadette Schröder, Janine Szybowicz, Janina Sauerwald, Kathrin Zopf, Agnieszka Grzywotz and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Sonja SiegelDepartment of Neurosurgery and Spine Surgery, University of Duisburg-Essen, Essen, Germany.
Nicole UngerDepartment of Endocrinology, Diabetology and Metabolism, University of Duisburg-Essen, Essen, Germany.
Christine Streetz-van der WerfDivision of Endocrinology and Diabetes, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University Hospital, Aachen, Germany.
Wolfram KargesDivision of Endocrinology and Diabetes, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University Hospital, Aachen, Germany.
Katharina SchilbachMedizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität (LMU) Klinikum, Munich, Germany.
Bernadette SchröderDepartment of Neurosurgery and Spine Surgery, University of Duisburg-Essen, Essen, Germany.
Janine SzybowiczDepartment of Neurosurgery and Spine Surgery, University of Duisburg-Essen, Essen, Germany.
Janina SauerwaldDepartment of Endocrinology, Diabetes and Nutritional Medicine, Charité Universitaetsmedizin, Berlin, Germany.
Kathrin ZopfDepartment of Endocrinology, Diabetes and Nutritional Medicine, Charité Universitaetsmedizin, Berlin, Germany.
Agnieszka GrzywotzDepartment of Neurosurgery and Spine Surgery, University of Duisburg-Essen, Essen, Germany.
Martin BidlingmaierMedizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität (LMU) Klinikum, Munich, Germany.
Cedric KirsteinDepartment of Neurosurgery and Spine Surgery, University of Duisburg-Essen, Essen, Germany.
Heide SommerHexal AG, Holzkirchen, Germany.
Christian J StrasburgerDepartment of Endocrinology, Diabetes and Nutritional Medicine, Charité Universitaetsmedizin, Berlin, Germany.
Ilonka Kreitschmann-AndermahrDepartment of Neurosurgery and Spine Surgery, University of Duisburg-Essen, Essen, Germany.
University of Duisburg-Essen · DECharité - Universitätsmedizin Berlin · DEHexal (Germany) · DELMU Klinikum · DELudwig-Maximilians-Universität München · DERWTH Aachen University · DEUniversitätsklinikum Aachen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Little is known about psychological reasons associated with adherence to growth hormone (GH) replacement therapy (GHRx) in adults. As in other chronic diseases, medication-related beliefs, coping strategies and disease impact on quality of life (QoL) might play an important role. We thus explored these psychological factors in relation to adherence in patients with GH deficiency (GHD) in order to find leverage points for the improvement of adherence. Patients and Methods: Cross-sectional analysis including 107 adult GHD patients on GHRx who completed self-assessment inventories on health-related QoL (Short-Form SF-36), coping style (Freiburg questionnaire on coping with illness, FKV-LIS) and medication beliefs (Beliefs about Medicine questionnaire, BMQ). Results were correlated to general and GH-specific adherence to medication. Results: In the BMQ, 92.5% of the patients (n=99) reported a strong belief in the need for their medication, which correlated significantly with general adherence (r Conclusion: We provide preliminary data that most GHD patients on GHRx are strongly convinced of their need for medication and that adherence to GHRx is influenced by coping strategies and QoL. Patients with impaired psychological QoL are less able to translate their convictions into good adherence, a phenomenon to be addressed in future research.

Indexed as

Medication AdherenceAdaptation, PsychologicalAdenomaAdultAgedCross-Sectional StudiesFemaleHormone Replacement TherapyHuman Growth HormoneHumansHypopituitarismMaleMiddle AgedPituitary NeoplasmsQuality of LifeHuman Growth Hormoneadherenceadult growth hormone deficiencybeliefs about medicationscopingquality of life

Identifiers

PMID34108940
PMCPMC8181747
OpenAlexW3165282510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.