ArticleFrontiers in aging neuroscience2021
Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic Cohort.
Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 61 papers, 2 of them syntheses that pooled it.
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Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Neurobiological correlates of Mild Behavioral Impairment: a systematic review and meta-analysis.Alzheimer's research & therapy · 2025Pooled it
- Risk factors of mild behavioral impairment: a systematic review.Frontiers in psychology · 2025Pooled it
- Neuropsychiatric symptoms and dementia development: a 15-year population-based study.The journal of prevention of Alzheimer's disease · 2026Article
- Phenotyping of mild behavioral impairment domains in multi-regional dementia-free older adults of Chinese ethnicity: impulse dyscontrol as the leading domain.The journal of prevention of Alzheimer's disease · 2026Article
- Right-lateralized cerebellar cortical thickening is associated with mild behavioral impairment in mild cognitive impairment.The journal of prevention of Alzheimer's disease · 2026Article
- Non-cognitive symptoms as early indicators of Dementia: a preliminary retrospective study from a Psychiatric outpatient clinic.BMC psychiatry · 2026Article
- Apathy in Mild Behavioural Impairment: Associations with Cortical Thickness and Grey Matter Volume.medRxiv : the preprint server for health sciences · 2026Article
- Facial Emotion Recognition Deficits and Electroencephalogram Alterations in Mild Behavioral Impairment.Neuro-degenerative diseases · 2026Article
- Neuropsychiatric symptoms in Alzheimer's disease: Past, present, and future.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Mild behavioural impairment-apathy and core Alzheimer's disease cerebrospinal fluid biomarkers.Brain : a journal of neurology · 2025Article
- Correlates of mild behavioural impairment in older adults: a scoping review.BMC geriatrics · 2025Article
- Neuropsychiatric symptoms and progression to pathologically confirmed Alzheimer's disease.Brain : a journal of neurology · 2025Article
- Late-life emergence of neuropsychiatric symptoms and risk of cognitive impairment in cognitively unimpaired individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Mild behavioral impairment in idiopathic REM sleep behavior disorder and Lewy body disease continuum.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Comorbid cerebrovascular and neurodegenerative burden in mild behavioural impairment and their impact on clinical trajectory.Acta neuropsychiatrica · 2025Article
- Structural covariance network patterns linked to neuropsychiatric symptoms in biologically defined Alzheimer's disease: Insights from the mild behavioral impairment checklist.Journal of Alzheimer's disease : JAD · 2025Article
- Updates and future perspectives on neuropsychiatric symptoms in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Advances in the study of apathy related to cerebral small vessel disease.Frontiers in neurology · 2025Review
- Observational
- Seeking the neural basis of neuropsychiatric symptoms in dementia: neuroimaging findings and controversies.Frontiers in aging neuroscience · 2025Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesMild behavioral impairment (MBI) is a syndrome describing late-onset persistent neuropsychiatric symptoms (NPS) in non-demented older adults. Few studies to date have investigated the associations of MBI with structural brain changes. Our aim was to explore structural correlates of NPS in a non-demented memory clinic sample using the Mild Behavioral Impairment Checklist (MBI-C) that has been developed to measure MBI.
methodsOne hundred sixteen non-demented older adults from the Czech Brain Aging Study with subjective cognitive concerns were classified as subjective cognitive decline (
resultsEntorhinal cortex was associated with MBI-C total score (
conclusionNeuropsychiatric symptoms, particularly in the MBI impulse dyscontrol and motivation domains, are associated with medial temporal lobe atrophy in a clinical cohort of non-demented older adults. This study supports earlier involvement of temporal rather than frontal regions in NPS manifestation. Since these regions are typically affected early in the course of Alzheimer's disease (AD), the MBI-C may potentially help further identify individuals at-risk of developing AD dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.