Evidence map›Paper›PMID 34108617›Full record

ArticleOncogene2021

αSMA

Kathleen M McAndrews, Karina Vázquez-Arreguín, Changsoo Kwak, Hikaru Sugimoto, Xiaofeng Zheng, Bingrui Li, Michelle L Kirtley, Valerie S LeBleu, Raghu Kalluri

Open access · greenAbstract read
In one paragraph

Article in Oncogene, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 41 citations in OpenAlex.

  1. Tumorigenesis and Tumor Microenvironment in Lung Cancer.Current issues in molecular biology · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. The intellectual base and research fronts of LGR5: a bibliometric analysis.Frontiers in research metrics and analytics · 2025
    Review
  9. Review
  10. Unraveling the role of cancer-associated fibroblasts in colorectal cancer.World journal of gastrointestinal oncology · 2024
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Fibroblasts in Orchestrating Colorectal Tumorigenesis and Progression.Cellular and molecular gastroenterology and hepatology · 2024
    Review
  16. Review
  17. Article
  18. Article
  19. Bifidobacterium adolescentis orchestrates CD143Cancer communications (London, England) · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kathleen M McAndrews *Metastasis Research Center, Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Karina Vázquez-Arreguín *Metastasis Research Center, Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Changsoo Kwak *Metastasis Research Center, Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hikaru SugimotoMetastasis Research Center, Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xiaofeng ZhengMetastasis Research Center, Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Bingrui LiMetastasis Research Center, Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Michelle L KirtleyMetastasis Research Center, Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Valerie S LeBleuMetastasis Research Center, Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Raghu KalluriMetastasis Research Center, Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. rkalluri@mdanderson.org.ORCID http://orcid.org/0000-0002-2190-547X
The University of Texas MD Anderson Cancer Center · USNorthwestern University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Training Grant in Cancer BiologyT32CA186892 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KALLURI, RAGHU · 2016 to 2020
$1.1M
NCI NIH HHS P30 CA016672NCI NIH HHS T32 CA186892
6 · The paper itself

Abstract

The development and progression of solid tumors is dependent on cancer cell autonomous drivers and the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) in the TME possess both tumor-promoting and tumor-restraining functions. In the current study, we interrogated the role of αSMA

Indexed as

ActinsAnimalsBone Morphogenetic Protein 4Cancer-Associated FibroblastsCD8-Positive T-LymphocytesCell Line, TumorCell MovementColorectal NeoplasmsDisease ProgressionForkhead Transcription FactorsMiceMice, Inbred C57BLNeoplasm InvasivenessNeoplastic Stem CellsReceptors, G-Protein-CoupledT-Lymphocytes, RegulatoryActinsalpha-smooth muscle actin, mouseBone Morphogenetic Protein 4Forkhead Transcription FactorsLgr5 protein, mouseReceptors, G-Protein-CoupledTransforming Growth Factor beta1

Identifiers

PMID34108617
PMCPMC9150816
OpenAlexW3170429403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.