Evidence map›Paper›PMID 34108581›Full record

ArticleScientific reports2021

Curcubinoyl flavonoids from wild ginseng adventitious root cultures.

Qing Liu, Seon Beom Kim, Yang Hee Jo, Jong Hoon Ahn, Ayman Turk, Da Eun Kim, Bo Yoon Chang, Sung Yeon Kim, Cheol-Seung Jeong, Bang Yeon Hwang and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Evaluating the Hepatoprotective Effect ofFood science & nutrition · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qing LiuCollege of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea.
Seon Beom KimCollege of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea.
Yang Hee JoCollege of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea.
Jong Hoon AhnCollege of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea.
Ayman TurkCollege of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea.
Da Eun KimCollege of Pharmacy, Wonkwang University, Iksan, 54538, Republic of Korea.
Bo Yoon ChangCollege of Pharmacy, Wonkwang University, Iksan, 54538, Republic of Korea.
Sung Yeon KimCollege of Pharmacy, Wonkwang University, Iksan, 54538, Republic of Korea.
Cheol-Seung JeongDepartment of Horticultural Science, Chungbuk National University, Cheongju, 28644, Republic of Korea.
Bang Yeon HwangCollege of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea.
So-Young ParkDepartment of Horticultural Science, Chungbuk National University, Cheongju, 28644, Republic of Korea. soypark7@chungbuk.ac.kr.
Mi Kyeong LeeCollege of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea. mklee@chungbuk.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wild ginseng (Panax ginseng) adventitious root cultures were prepared by elicitation using methyl jasmonate and investigated further to find new secondary metabolites. Chromatographic fractionation of wild ginseng adventitious root cultures led to the isolation of eleven compounds. The chemical structures of isolated compounds were identified as four known flavanone derivatives (1-4), one new curcubinoyl derivative, jasmogin A (5) and six new curcubinoyl-flavanone conjugates, jasmoflagins A-F (6-11) by extensive spectroscopic analysis. Newly isolated curcubinoyl derivatives showed inhibitory activity against lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 macrophages. Therefore, our present study suggested that elicitor stimulated plant cell cultures might contribute to the production of new metabolites.

Indexed as

AnimalsFlavonoidsGinsenosidesLipopolysaccharidesMacrophagesMiceNitric OxidePanaxPlant RootsRAW 264.7 CellsFlavonoidsGinsenosidesLipopolysaccharidesNitric Oxide

Identifiers

PMID34108581
PMCPMC8190163

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.