Evidence map›Paper›PMID 34108528›Full record

SynthesisScientific reports2021

Systematic review and meta-analysis on the adjunctive use of host immune modulators in non-surgical periodontal treatment in healthy and systemically compromised patients.

Stefano Corbella, Elena Calciolari, Alice Alberti, Nikolaos Donos, Luca Francetti

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07117097 (Minimally Invasive Non- Surgical Periodontal Therapy of Intrabony Defects), which is not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07117097 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Minimally Invasive Non- Surgical Periodontal Therapy of Intrabony Defects: Molecular Healing Patterns and the Impact of Smoking on Outcomes

TypeinterventionalSponsorUniversity of TurkuRan2025 to 2027Enrolled120ConditionsPeriodontitisArmsMinimally Invasive Non- Surgical Periodontal Therapy (MINST), conventional Non-Surgical Periodontal Treatment (cNSPT)
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Stefano CorbellaDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy. stefano.corbella@gmail.com.ORCID 0000-0001-8428-8811
Elena CalciolariCentre for Oral Clinical Research and Centre for Oral Immunobiology and Regenerative Medicine, Institute of Dentistry, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0001-8781-1997
Alice AlbertiDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0001-5017-1340
Nikolaos DonosCentre for Oral Clinical Research and Centre for Oral Immunobiology and Regenerative Medicine, Institute of Dentistry, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-4117-9073
Luca FrancettiDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0001-5775-8961
University of Milan · ITQueen Mary University of London · GBSechenov University · RUUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering the central role of inflammation in the pathogenesis of periodontitis, the combination of NSPT with different agents that can modulate the host immune-inflammatory response has been proposed to enhance the outcomes of NSPT. The aim of this paper is to systematically review the literature on the efficacy of systemic host modulators (HMs) as adjuncts to non-surgical periodontal therapy (NSPT) in improving pocket depth (PD) reduction and clinical attachment level (CAL) gain in healthy and systemically compromised patients. RCTs with ≥ 3 months follow-up were independently searched by two reviewers. Meta-analysis was performed when ≥ 3 studies on the same HM were identified. The quality of the evidence was rated according to the GRADE approach to rate the certainty of evidence. 38 articles were included in the qualitative assessment and 27 of them were included in the meta-analysis. There is low/very low evidence that the adjunctive use of sub-antimicrobial dose of doxycicline, melatonin and the combination of omega-3 and low dose aspirin (in type 2 diabetic patients) to NSPT would improve PD and/or CAL. Conflicting evidence is available on the efficacy of probiotics. Future studies controlling for confounding factors, using composite outcomes to define the endpoint of therapy and considering not only the patient- but also as the site-specific effect of systemic HMs are warranted. The dosage, posology and long-term effect of HMs still need to be clarified, also in association to the presence of systemic conditions potentially affecting the response to HMs administration.

Indexed as

Anti-Infective AgentsAnti-Inflammatory Agents, Non-SteroidalAntioxidantsAspirinChronic DiseaseHumansMelatoninPeriodontitisPrognosisAnti-Infective AgentsAnti-Inflammatory Agents, Non-SteroidalAntioxidantsAspirinMelatonin

Identifiers

PMID34108528
PMCPMC8190303
OpenAlexW3170136205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.