Evidence map›Paper›PMID 34108512›Full record

ArticleScientific reports2021

Real-Time insight into in vivo redox status utilizing hyperpolarized [1-

Kazutoshi Yamamoto, Ana Opina, Deepak Sail, Burchelle Blackman, Keita Saito, Jeffrey R Brender, Ronja M Malinowski, Tomohiro Seki, Nobu Oshima, Daniel R Crooks and 9 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Kazutoshi YamamotoCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Ana OpinaChemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD, 20850, USA.
Deepak SailChemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD, 20850, USA.
Burchelle BlackmanChemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD, 20850, USA.
Keita SaitoCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Jeffrey R BrenderCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Ronja M MalinowskiDepartment of Electrical Engineering, Technical University of Denmark, 2800, Lyngby, Denmark.
Tomohiro SekiCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Nobu OshimaCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Daniel R CrooksCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Shun KishimotoCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Yu SaidaCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Yasunori OtowaCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Peter L ChoykeCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Jan H Ardenkjær-LarsenDepartment of Electrical Engineering, Technical University of Denmark, 2800, Lyngby, Denmark.
James B MitchellCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
W Marston LinehanCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Rolf E SwensonChemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD, 20850, USA.
Murali C KrishnaCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA. cherukum@mail.nih.gov.
National Cancer Institute · USNational Institutes of Health · USCenter for Cancer Research · USNational Heart Lung and Blood Institute · USTechnical University of Denmark · DK

Funding

Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase GeneZIABC011038 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LINEHAN, WILLIAM MARSTON · 2009 to 2025
$29.8M
Intracellular In vivo ImagingZIABC010657 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2025
$20.3M
Metabolomics CoreZICBC011932 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CROOKS, DANIEL · 2020 to 2025
$11.6M
6 · The paper itself

Abstract

Drastic sensitivity enhancement of dynamic nuclear polarization is becoming an increasingly critical methodology to monitor real-time metabolic and physiological information in chemistry, biochemistry, and biomedicine. However, the limited number of available hyperpolarized

Indexed as

AcetylcysteineAnimalsApoptosisBrainCarbon IsotopesCell ProliferationGlutathioneHumansMagnetic Resonance ImagingMiceOxidation-ReductionPancreatic NeoplasmsTumor Cells, CulturedXenograft Model Antitumor AssaysAcetylcysteineCarbon IsotopesGlutathione

Identifiers

PMID34108512
PMCPMC8190077
OpenAlexW3166809195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.