ArticleNature communications2021
Brain network dynamics during working memory are modulated by dopamine and diminished in schizophrenia.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed, 174 citations in OpenAlex.
- Optimizing tDCS cognitive outcomes in schizophrenia: the role of dopaminergic tone and antipsychotic load.Translational psychiatry · 2026Trial
- Dopamine and Temporal Discounting: Revisiting Pharmacology and Individual Differences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Trial
- Catecholaminergic Modulation of Large-Scale Network Dynamics Is Tied to the Reconfiguration of Corticostriatal Connectivity.Human brain mapping · 2024Trial
- Mindful attention promotes control of brain network dynamics for self-regulation and discontinues the past from the present.Proceedings of the National Academy of Sciences of the United States of America · 2023Trial
- Dynamical system modeling in schizophrenia: a narrative review of computational psychiatry frameworks.Dialogues in clinical neuroscience · 2026Review
- Neurochemically informed network control theory reveals energetic dysregulation of altered brain state dynamics in obsessive-compulsive disorder.Psychiatry and clinical neurosciences · 2026Article
- Optimizing brain functional-structural architecture with cTBS to reduce relapse in alcohol use disorder: a randomized controlled trial.Molecular psychiatry · 2026Article
- Age of Onset, Brain Controllability, and Working Memory Performance in First-Episode Schizophrenia.Schizophrenia bulletin · 2026Article
- Divergent transcriptomic pathways underlie sex-biased cognitive rescue by developmental GSK3B inhibition in a mouse model of 22q11.2 deletion syndrome.Translational psychiatry · 2026Article
- Energy-Based Phase-Locking State Analysis in Brain State Identification.Human brain mapping · 2026Article
- Large-scale brain dynamics are organized by a directional coordination hierarchy.bioRxiv : the preprint server for biology · 2026Article
- Genetic Risk and Resilience for Schizophrenia Stratified by Perinatal Gene Expression Predict Adult Cognitive Performance.bioRxiv : the preprint server for biology · 2026Article
- Association-sensory spatiotemporal hierarchy and functional gradient-regularised recurrent neural network with implications for schizophrenia.NPJ systems biology and applications · 2026Article
- Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity.Nature communications · 2026Article
- Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma.Psychological medicine · 2026Article
- Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains.Nature human behaviour · 2026Article
- Exploring the Role of the Rich Club in Network Control of Neurocognitive States.Human brain mapping · 2026Article
- Controlling the human connectome with spatially diffuse input signals.Communications biology · 2026Article
- Post-mortem brain analysis reveals altered monoaminergic system in the dorsolateral prefrontal cortex and hippocampus in chronic schizophrenia.Schizophrenia (Heidelberg, Germany) · 2026Article
- Habit learning is associated with efficiently controlled network dynamics in naive macaque monkeys.Npj complexity · 2026Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 6 institutions in 3 countries.
Funding
Abstract
Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory performance entails brain-wide switching between activity states using a combination of functional magnetic resonance imaging in healthy controls and individuals with schizophrenia, pharmacological fMRI, genetic analyses and network control theory. The stability of states relates to dopamine D1 receptor gene expression while state transitions are influenced by D2 receptor expression and pharmacological modulation. Individuals with schizophrenia show altered network control properties, including a more diverse energy landscape and decreased stability of working memory representations. Our results demonstrate the relevance of dopamine signaling for the steering of whole-brain network dynamics during working memory and link these processes to schizophrenia pathophysiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.