Evidence map›Paper›PMID 34108238›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Involvement of Scratch2 in GalR1-mediated depression-like behaviors in the rat ventral periaqueductal gray.

Yutao Yang, Yueting Li, Bo Liu, Chenchen Li, Zijin Liu, Jiahui Deng, Hanjiang Luo, Xiaoxiao Li, Jinjin Wu, Hui Li and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yutao YangDepartment of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Capital Medical University, 100069 Beijing, China.ORCID 0000-0002-6835-2964
Yueting LiDepartment of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Capital Medical University, 100069 Beijing, China.
Bo LiuDepartment of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Capital Medical University, 100069 Beijing, China.
Chenchen LiDepartment of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Capital Medical University, 100069 Beijing, China.
Zijin LiuDepartment of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Capital Medical University, 100069 Beijing, China.ORCID 0000-0002-3140-2593
Jiahui DengBeijing Key Laboratory of Epilepsy, Sanbo Brain Hospital, Capital Medical University, 100069 Beijing, China.
Hanjiang LuoDepartment of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Capital Medical University, 100069 Beijing, China.
Xiaoxiao LiDepartment of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Capital Medical University, 100069 Beijing, China.
Jinjin WuDepartment of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Capital Medical University, 100069 Beijing, China.
Hui LiDepartment of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Capital Medical University, 100069 Beijing, China.
Chuan-Yue WangAnding Hospital, Capital Medical University, 100088 Beijing, China.ORCID 0000-0001-6549-3713
Ming ZhaoDepartment of Neuroscience, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Haohao WuDepartment of Neuroscience, Karolinska Institutet, SE-17177 Stockholm, Sweden.ORCID 0000-0002-5511-7084
Francois LallemendDepartment of Neuroscience, Karolinska Institutet, SE-17177 Stockholm, Sweden.ORCID 0000-0001-5484-0011
Per SvenningssonCenter for Molecular Medicine, Department of Neurology and Clinical Neuroscience, Karolinska Institutet and Karolinska University Hospital, SE-17176 Stockholm, Sweden.
Tomas G M HökfeltDepartment of Neuroscience, Karolinska Institutet, SE-17177 Stockholm, Sweden; tomas.hokfelt@ki.se zhiqingx@ccmu.edu.cn.ORCID 0000-0002-3587-0116
Zhi-Qing David XuDepartment of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Capital Medical University, 100069 Beijing, China; tomas.hokfelt@ki.se zhiqingx@ccmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Galanin receptor1 (GalR1) transcript levels are elevated in the rat ventral periaqueductal gray (vPAG) after chronic mild stress (CMS) and are related to depression-like behavior. To explore the mechanisms underlying the elevated GalR1 expression, we carried out molecular biological experiments in vitro and in animal behavioral experiments in vivo. It was found that a restricted upstream region of the

Indexed as

Behavior, AnimalAnimalsDepressionE-Box ElementsGABAergic NeuronsGene Expression RegulationGlutamic AcidPC12 CellsPeriaqueductal GrayPromoter Regions, GeneticProtein BindingRatsReceptor, Galanin, Type 1Stress, PsychologicalTranscription FactorsTranscription Initiation SiteGlutamic AcidReceptor, Galanin, Type 1Scrt2 protein, ratTranscription Factorsgalaninneuropeptidesstresstranscription factortransmitter coexistence

Identifiers

PMID34108238
PMCPMC8214687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.