Evidence map›Paper›PMID 34108231›Full record

ArticleRNA (New York, N.Y.)2021

Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.

Samantha T Johnson, Yongjun Chu, Jing Liu, David R Corey

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Trauma-induced alterations in bone marrow exosome microRNA profiles.The journal of trauma and acute care surgery · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Samantha T JohnsonUT Southwestern Medical Center, Departments of Pharmacology and Biochemistry, Dallas, Texas 75205, USA.
Yongjun ChuUT Southwestern Medical Center, Departments of Pharmacology and Biochemistry, Dallas, Texas 75205, USA.
Jing LiuUT Southwestern Medical Center, Departments of Pharmacology and Biochemistry, Dallas, Texas 75205, USA.
David R CoreyUT Southwestern Medical Center, Departments of Pharmacology and Biochemistry, Dallas, Texas 75205, USA.
Southwestern Medical Center · US

Funding

Recognition of Cellular Targets by single and double-stranded nucleic acidsR35GM118103 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI David R Corey · 2016 to 2026
$5.7M
Mechanism of RNA-Mediated Control of Transcription or SplicingR01GM106151 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI COREY, DAVID R · 2014 to 2016
$859k
Exploring the link between mutant RNA expression and trinucleotide repeat diseaseF31EY030336 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI JOHNSON, SAMANTHA TORI · 2019 to 2021
$102k
NEI NIH HHS F31 EY030336NIGMS NIH HHS R01 GM106151NIGMS NIH HHS R35 GM118103
6 · The paper itself

Abstract

TNRC6 is a scaffolding protein that bridges interactions between small RNAs, argonaute (AGO) protein, and effector proteins to control gene expression. There are three paralogs in mammalian cells,

Indexed as

Alternative SplicingArgonaute ProteinsAutoantigensBinding SitesCell Line, TumorExonsGene Knockout TechniquesHCT116 CellsHumansImmunoprecipitationIntronsProtein BindingRNA-Binding ProteinsSequence Analysis, RNAAGO2 protein, humanArgonaute ProteinsAutoantigensRNA-Binding ProteinsTNRC6A protein, humanTNRC6B protein, humanTNRC6C protein, humanalternative splicingArgonauteGW182RNA interferenceRNA sequencingTNRC6

Identifiers

PMID34108231
PMCPMC8370741
OpenAlexW3172028694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.