Evidence map›Paper›PMID 34108218›Full record

ArticleScience advances2021

Mesenchymal growth hormone receptor deficiency leads to failure of alveolar progenitor cell function and severe pulmonary fibrosis.

Ting Xie, Vrishika Kulur, Ningshan Liu, Nan Deng, Yizhou Wang, Simon Coyle Rowan, Changfu Yao, Guanling Huang, Xue Liu, Forough Taghavifar and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Arrestin beta 1 Regulates Alveolar Progenitor Renewal and Lung Fibrosis.Journal of respiratory biology and translational medicine · 2024
    Article
  8. Cell-cell interactions and communication dynamics in lung fibrosis.Chinese medical journal pulmonary and critical care medicine · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Persistency of Mesenchymal Stromal/Stem Cells in Lungs.Frontiers in cell and developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Ting XieDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-9958-3888
Vrishika KulurDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-2643-2122
Ningshan LiuDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Nan DengBiostatistics and Bioinformatics Research Center, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0003-0914-7220
Yizhou WangGenomics Core, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Simon Coyle RowanDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-4103-4421
Changfu YaoDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0003-1357-5017
Guanling HuangDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Xue LiuDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Forough TaghavifarDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jiurong LiangDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-5179-5016
Cory HogaboamDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0003-3366-4850
Barry StrippDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0003-4348-2137
Peter ChenDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-5330-1718
Dianhua JiangDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-4508-3829
Paul W NobleDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. paul.noble@cshs.org.ORCID 0000-0001-7922-2295
Cedars-Sinai Medical Center · US

Funding

Role of Surfactant Proteins in Mediating Noninfectious Inflammatory and FibroproP01HL108793 · NHLBI · DUKE UNIVERSITY · PI STRIPP, BARRY R · 2012 to 2022
$21.3M
MECHANISMS OF MACROPHAGE ACTIVATION IN LUNG INFLAMMATIONR01HL060539 · NHLBI · YALE UNIVERSITY · PI NOBLE, PAUL WESLEY · 1997 to 2019
$6.5M
Innate Immune Mechanisms of Non-infectious Lung InflammationR01AI052201 · NIAID · YALE UNIVERSITY · PI NOBLE, PAUL WESLEY · 2002 to 2021
$6.4M
Molecular Regulation of Progressive Pulmonary FibrosisR35HL150829 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Paul Wesley Noble · 2020 to 2026
$5.7M
Targeting beta-arrestins in Pulmonary FibrosisR01HL122068 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI JIANG, DIANHUA, NOBLE, PAUL WESLEY · 2015 to 2018
$2.1M
Innate DNA sensing in rapidly progressing IPFR01HL123899 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI HOGABOAM, CORY M · 2015 to 2018
$2.0M
Novel agents for idiopathic pulmonary fibrosisR43HL150986 · NHLBI · EPIGEN BIOSCIENCES, INC. · PI HOGABOAM, CORY M, TUCCI, FABIO COHEN · 2020 to 2020
$300k
NHLBI NIH HHS P01 HL108793NHLBI NIH HHS R01 HL060539NHLBI NIH HHS R01 HL122068NHLBI NIH HHS R01 HL123899NHLBI NIH HHS R35 HL150829NIAID NIH HHS R01 AI052201
6 · The paper itself

Abstract

Recent studies have identified impaired type 2 alveolar epithelial cell (ATII) renewal in idiopathic pulmonary fibrosis (IPF) human organoids and severe fibrosis when ATII is defective in mice. ATIIs function as progenitor cells and require supportive signals from the surrounding mesenchymal cells. The mechanisms by which mesenchymal cells promote ATII progenitor functions in lung fibrosis are incompletely understood. We identified growth hormone receptor (GHR) is mainly expressed in mesenchymal cells, and its expression is substantially decreased in IPF lungs. Higher levels of

Indexed as

Idiopathic Pulmonary FibrosisAlveolar Epithelial CellsAnimalsHumansLaron SyndromeLungMiceStem Cells

Identifiers

PMID34108218
PMCPMC8189579
OpenAlexW3171589667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.