Evidence map›Paper›PMID 34108154›Full record

ArticleBMJ case reports2021

Lithium-induced ECG modifications: navigating from acute coronary syndrome to Brugada syndrome.

Léonard Diserens, Alessandra Pia Porretta, Catalina Trana, David Meier

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Lithium Treatment Induces Cardiac Dysfunction in Mice.International journal of molecular sciences · 2023
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Léonard DiserensDepartment of Internal Medicine, Hopital Riviera-Chablais, Rennaz, Switzerland.
Alessandra Pia PorrettaDepartment of Cardiology, CHUV, Lausanne, Switzerland.
Catalina TranaDepartment of Cardiology, Hopital Riviera-Chablais, Rennaz, Switzerland catalina.trana@gmail.com.
David MeierDepartment of Cardiology, CHUV, Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lithium is frequently used in the treatment of bipolar disorders and is known to induce ECG alterations. This case study describes various patterns of lithium-induced ECG modifications in a patient with acute-on-chronic lithium intoxication. Clinicians should be familiar with this problem as it can have life-threatening consequences and lead to important changes in patient's management. Our patient was admitted for acute delirium with an ECG showing atrial fibrillation with wide QRS and ST-segment elevation. These modifications were first mistaken for an acute myocardial infarction and a diagnosis of Brugada syndrome was finally reached. Treatment after the acute phase implied changes in the therapeutic modality and required frequent monitoring.

Indexed as

Acute Coronary SyndromeAtrial FibrillationBrugada SyndromeElectrocardiographyHumansLithiumLithiumarrhythmiascardiovascular systemgenetic screening / counsellingmood disorders (including depression)

Identifiers

PMID34108154
PMCPMC8191624

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.