SynthesisBMJ open respiratory research2021
Sudden death in individuals with obstructive sleep apnoea: a systematic review and meta-analysis.
Synthesis in BMJ open respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Comparative effects of hypnotic agents on sleep architecture and respiratory outcomes in obstructive sleep apnea: A systematic review and network meta-analysis.Psychiatry and clinical neurosciences · 2026Pooled it
- Positive airway pressure therapy and all-cause and cardiovascular mortality in people with obstructive sleep apnoea: a systematic review and meta-analysis of randomised controlled trials and confounder-adjusted, non-randomised controlled studies.The Lancet. Respiratory medicine · 2025Pooled it
- Sleep disorders and associated factors among medical students in the Middle East and North Africa: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Predictor of Mortality in Obstructive Sleep Apnea: Results of Explainable Deep Learning-Based Survival Analysis from a 15-Year Follow-Up.Respiration; international review of thoracic diseases · 2026Article
- Severe respiratory complications in late-diagnosed Prader-Willi syndrome: a case report.Journal of medical case reports · 2026Article
- Dose-response relationship of sleep apnea therapy and healthcare use in patients with comorbidities.Sleep · 2026Article
- The impact of positive airway pressure treatment on mortality and hospitalisation in obstructive sleep apnoea: a German database analysis.ERJ open research · 2026Article
- Systemic inflammatory response index is associated with increased all-cause and cardiovascular mortality in obstructive sleep apnea: evidence from NHANES and validation with an external hospital-based dataset.Frontiers in medicine · 2026Article
- Body Mass Index and Hypoglossal Nerve Stimulation Outcomes: A Systematic Review and Meta-Analysis.Laryngoscope investigative otolaryngology · 2025Review
- Obstructive sleep apnea in type 2 diabetes: prevalence and limitations of the Berlin questionnaire and Epworth sleepiness scale in identifying high-risk patients.Sleep & breathing = Schlaf & Atmung · 2025Article
- Associations between home gardening and obstructive sleep apnoea: role of behavioural factors in the COMmunity-based Behaviour and Attitude Study in Tuvalu (COMBAT).Journal of global health · 2025Article
- Does Surgical Treatment With Uvulopalatopharyngoplasty for Obstructive Sleep Apnea Prevent Future Arrhythmic Events?Pacing and clinical electrophysiology : PACE · 2025Article
- Orofacial pain/headache interlaced to insomnia, sleep apnea and periodic limb movement during sleep/restless leg syndrome: a critical and comprehensive review with insights into social determinants.Journal of oral & facial pain and headache · 2025Review
- The Association between All-Cause Mortality and Obstructive Sleep Apnea in Adults: A U-Shaped Curve.Annals of the American Thoracic Society · 2025Article
- Barriers and facilitators to detection and treatment of obstructive sleep apnoea syndrome in people with severe mental illnesses, qualitative interview study and referrer survey.BMC psychiatry · 2025Article
- Association of Novel Hematologic Inflammatory Biomarkers with Cardiovascular Disease in Patients with Obstructive Sleep Apnea.Nature and science of sleep · 2025Article
- A Qualitative Study to Investigate the Preference of Older Individuals with Obstructive Sleep Apnea on a Continuous Positive Airway Pressure Machine in Thailand: An Outpatient Setting.Patient preference and adherence · 2025Article
- Long-term mortality risk in obstructive sleep apnea: the critical role of oxygen desaturation index.Sleep & breathing = Schlaf & Atmung · 2024Article
- Altered ventricular repolarisation dynamic: the missing link between obstructive sleep apnoea and sudden death?ERJ open research · 2024Article
- Age modifies the association between severe sleep apnea and all-cause mortality.Sleep medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOver 1 billion individuals worldwide experience some form of sleep apnoea, and this number is steadily rising. Obstructive sleep apnoea (OSA) can negatively influence one's quality of life and potentially increase mortality risk. However, the association between OSA and mortality has not been reliably estimated. This meta-analysis estimates the risk of all-cause and cardiovascular mortality in individuals with OSA.
designSystematic review and meta-analysis. DATA SOURCES: MEDLINE, Cochrane Library, Scopus and Joanna Briggs Institute Evidence-Based Practice databases were searched from inception through 1 January 2020. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: We included observational studies assessing the association of sudden deaths in individuals with and without OSA. DATA EXTRACTION AND SYNTHESIS: Two independent reviewers (AES and ESH) extracted data and assessed the risk of bias using the Newcastle-Ottawa Scale quality assessment tool. Data were pooled using the random-effects models and reported as risk ratios (RRs) with 95% CIs. Heterogeneity was quantified with I
resultsWe identified 22 observational studies (n=42 099 participants). The mean age was 62 years and 64% were men. OSA was associated with all-cause sudden death (RR=1.74, 95% CI: 1.44 to 2.10, I
conclusionsOSA is a significant risk factor for all-cause mortality and cardiac mortality. Prevention and treatment strategies to optimise survival and quality of life in individuals with OSA are urgently needed. PROSPERO REGISTRATION NUMBER: CRD42020164941.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.