Evidence map›Paper›PMID 34108003›Full record

Observational studyJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2021

Prognostic value of cardiovascular magnetic resonance left ventricular volumetry and geometry in patients receiving an implantable cardioverter defibrillator.

Camila M Urzua Fresno, Luciano Folador, Tamar Shalmon, Faisal Mhd Dib Hamad, Sheldon M Singh, Gauri R Karur, Nigel S Tan, Iqwal Mangat, Anish Kirpalani, Binita Riya Chacko and 3 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 5 countries.

Camila M Urzua FresnoDepartment of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Canada.
Luciano FoladorDepartment of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Canada.
Tamar ShalmonDepartment of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Canada.
Faisal Mhd Dib HamadDepartment of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Canada.
Sheldon M SinghSchulich Heart Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
Gauri R KarurJoint Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada.
Nigel S TanDivision of Cardiology, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Canada.
Iqwal MangatDivision of Cardiology, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Canada.
Anish KirpalaniDepartment of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Canada.
Binita Riya ChackoDepartment of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
Laura Jimenez-JuanDepartment of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Canada.
Andrew T YanDepartment of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Canada. Andrew.Yan@unityhealth.to.
Djeven P DevaDepartment of Medical Imaging, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Canada. Djeven.Deva@unityhealth.to.ORCID 0000-0002-3347-008X
St. Michael's Hospital · CASunnybrook Health Science Centre · CAUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrent indications for implantable cardioverter defibrillator (ICD) implantation for sudden cardiac death prevention rely primarily on left ventricular (LV) ejection fraction (LVEF). Currently, two different contouring methods by cardiovascular magnetic resonance (CMR) are used for LVEF calculation. We evaluated the comparative prognostic value of these two methods in the ICD population, and if measures of LV geometry added predictive value.

methodsIn this retrospective, 2-center observational cohort study, patients underwent CMR prior to ICD implantation for primary or secondary prevention from January 2005 to December 2018. Two readers, blinded to all clinical and outcome data assessed CMR studies by: (a) including the LV trabeculae and papillary muscles (TPM) (trabeculated endocardial contours), and (b) excluding LV TPM (rounded endocardial contours) from the total LV mass for calculation of LVEF, LV volumes and mass. LV sphericity and sphere-volume indices were also calculated. The primary outcome was a composite of appropriate ICD shocks or death.

resultsOf the 372 consecutive eligible patients, 129 patients (34.7%) had appropriate ICD shock, and 65 (17.5%) died over a median duration follow-up of 61 months (IQR 38-103). LVEF was higher when including TPM versus excluding TPM (36% vs. 31%, p < 0.001). The rate of appropriate ICD shock or all-cause death was higher among patients with lower LVEF both including and excluding TPM (p for trend = 0.019 and 0.004, respectively). In multivariable models adjusting for age, primary prevention, ischemic heart disease and late gadolinium enhancement, both LVEF (HR per 10% including TPM 0.814 [95%CI 0.688-0.962] p = 0.016, vs. HR per 10% excluding TPM 0.780 [95%CI 0.639-0.951] p = 0.014) and LV mass index (HR per 10 g/m

conclusionBoth CMR post-processing methods showed similar prognostic value and can be used for LVEF assessment. LVEF and indexed LV mass are independent predictors for appropriate ICD shocks and all-cause mortality in the ICD population.

Indexed as

Defibrillators, ImplantableContrast MediaGadoliniumHumansMagnetic Resonance SpectroscopyPredictive Value of TestsPrognosisRetrospective StudiesRisk FactorsContrast MediaGadoliniumCardiovascular magnetic resonanceImplantable cardioverter defibrillatorLeft ventricular ejection fractionLeft ventricular sphericityPapillary musclesSudden cardiac death

Identifiers

PMID34108003
PMCPMC8191093
OpenAlexW3168828338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.