SynthesisJournal of orthopaedic surgery and research2021
The use of extracorporeal shock wave therapy for the treatment of bone marrow oedema - a systematic review and meta-analysis.
Synthesis in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Extracorporeal shock wave therapy for temporomandibular disorders: efficacy on pain, maximal mouth opening, and dysfunction-a meta-analysis of randomized controlled trials.Frontiers in rehabilitation sciences · 2026Pooled it
- Bone marrow edema of the femoral head treated with extracorporeal magnetotransduction therapy and conservative management: a case series.Journal of medical case reports · 2026Article
- Periostitis of the Pubic Symphysis in Inguinal and Femoral Hernia: An Uninterpreted Source of Chronic Groin Pain.Medicina (Kaunas, Lithuania) · 2026Review
- Rehabilitation in Kienböck Disease: A Narrative Review of Current Concepts.Journal of clinical medicine · 2026Review
- Article
- Avoiding Hallux Sesamoidectomy: A Narrative Review.Journal of clinical medicine · 2025Review
- [The value of physical therapy modalities for osteonecrosis and bone marrow edema : Current study situation and practical applicability in everyday clinical practice].Orthopadie (Heidelberg, Germany) · 2025Article
- Conservative treatments of bone marrow lesions.Journal of experimental orthopaedics · 2025Article
- Effect of Extracorporeal Shock Wave on IGF-1, TNF-α, and IL-1in Joint Fluid of Patients with Temporomandibular Joint Disorder Syndrome.Cell biochemistry and biophysics · 2025Article
- Review
- Bone marrow edema of the knee: a narrative review.Archives of orthopaedic and trauma surgery · 2024Review
- No dose response effect in shockwave therapy applied to bone conditions: a systematic review, meta-analysis and meta-regression.Journal of orthopaedics · 2024Review
- Bone marrow edema in a postpartum female following ankle sprain: a case report.World journal of emergency medicine · 2024Article
- Bone marrow edema of the hip: a narrative review.Archives of orthopaedic and trauma surgery · 2023Review
- Extracorporeal Shock Wave Therapy for the Treatment of Musculoskeletal Pain: A Narrative Review.Healthcare (Basel, Switzerland) · 2023Review
- Shock Waves and Therapeutic Exercise in Greater Trochanteric Pain Syndrome: A Prospective Randomized Clinical Trial with Cross-Over.Journal of personalized medicine · 2023Article
- The Institute of Physical Medicine and Rehabilitation, Hospital das Clínicas University of São Paulo School of Medicine comprehensive rehabilitation program for elderly people with knee osteoarthritis.Frontiers in medicine · 2022Article
- Multimodal conservative treatment of migrating bone marrow edema associated with early osteonecrosis of the hip.SAGE open medical case reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtracorporeal shock wave therapy (ESWT) has been used for various pathologies associated with bone marrow oedema (BME). However, it is still not clear whether ESWT may be favourable in the treatment of BME. Therefore, the aim of this systematic review was to assess the efficacy of ESWT for the treatment of BME.
methodsMEDLINE was searched for relevant literature with no time constraints. Both randomized and non-randomized trials were included. Case reports and conference abstracts were excluded. Titles and abstracts were screened and full-text articles of included studies were retrieved. Data on the effect of ESWT on pain, function, and the BME area on magnet resonance imaging were extracted.
resultsPain, function, and magnet resonance imaging results all improved across the studies - regardless of whether it was a randomized or non-randomized study. This effect was consistent across multiple pathologies such as osteonecrosis of the femoral head, BME associated with knee osteoarthritis, Kienböck's disease, and osteitis pubis. The meta-analysis showed that pain (after 1 month: weighted mean difference (WMD) = - 2.23, 95% CI - 2.58 to - 1.88, P < 0.0001; after 3-6 month: WMD = - 1.72, 95% CI - 2.52 to - 0.92, P < 0.00001) and function (after 1 month: WMD = - 1.59, 95% CI - 2.04 to - 1.14, P < 0.0001; after 3-6 month: WMD = - 2.06, 95% CI - 3.16 to - 0.96, P = 0.0002; after ≥ 12 month: WMD = - 1.20, 95% CI - 1.83 to - 0.56, P = 0.0002) was reduced in terms of ESWT treatment compared to a control group.
conclusionsBased on the available evidence, ESWT may be an adequate option for conservative therapy in pathologies involving BME.
trial registrationPROSPERO, CRD42021201719 . Registered 23 December 2020.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.