Evidence map›Paper›PMID 34107947›Full record

ArticleBMC public health2021

Geographic and demographic heterogeneity of SARS-CoV-2 diagnostic testing in Illinois, USA, March to December 2020.

Tobias M Holden, Reese A K Richardson, Philip Arevalo, Wayne A Duffus, Manuela Runge, Elena Whitney, Leslie Wise, Ngozi O Ezike, Sarah Patrick, Sarah Cobey and 1 more

Open access · goldAbstract read
In one paragraph

Article in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  6. Excess natural-cause mortality in US counties and its association with reported COVID-19 deaths.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  11. SARS-CoV-2 self-test uptake and factors associated with self-testing during Omicron BA.1 and BA.2 waves in France, January to May 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Article
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  15. Article
  16. Improvements in Severe Acute Respiratory Syndrome Coronavirus 2 Testing Cascade in the United States: Data From Serial Cross-sectional Assessments.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  17. Heterogeneity in testing for infectious diseases.Royal Society open science · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Tobias M Holden *Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Reese A K Richardson *Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.
Philip ArevaloDepartment of Ecology and Evolutionary Biology, University of Chicago, Chicago, IL, USA.
Wayne A DuffusCenter for Preparedness and Response, Division of State and Local Readiness, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Manuela RungeDepartment of Preventive Medicine and Institute for Global Health, Northwestern University, Chicago, IL, USA.
Elena WhitneyDepartment of Ecology and Evolutionary Biology, University of Chicago, Chicago, IL, USA.
Leslie WiseIllinois Department of Public Health, Springfield, IL, USA.
Ngozi O EzikeIllinois Department of Public Health, Springfield, IL, USA.
Sarah PatrickIllinois Department of Public Health, Springfield, IL, USA.
Sarah CobeyDepartment of Ecology and Evolutionary Biology, University of Chicago, Chicago, IL, USA.
Jaline GerardinDepartment of Preventive Medicine and Institute for Global Health, Northwestern University, Chicago, IL, USA. jgerardin@northwestern.edu.
Illinois Department of Public Health · USNorthwestern University · USUniversity of Chicago · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0M
Developing Capacity to Evaluate Training Programs via Development of Human, Institutional and Social CapitalT32GM008449 · NIGMS · NORTHWESTERN UNIVERSITY · PI LEONARD, JOSHUA NATHANIEL · 1993 to 2023
$7.8M
NCATS NIH HHS UL1 TR001422NIGMS NIH HHS T32 GM008152NIGMS NIH HHS T32 GM008449
6 · The paper itself

Abstract

backgroundAvailability of SARS-CoV-2 testing in the United States (U.S.) has fluctuated through the course of the COVID-19 pandemic, including in the U.S. state of Illinois. Despite substantial ramp-up in test volume, access to SARS-CoV-2 testing remains limited, heterogeneous, and insufficient to control spread.

methodsWe compared SARS-CoV-2 testing rates across geographic regions, over time, and by demographic characteristics (i.e., age and racial/ethnic groups) in Illinois during March through December 2020. We compared age-matched case fatality ratios and infection fatality ratios through time to estimate the fraction of SARS-CoV-2 infections that have been detected through diagnostic testing.

resultsBy the end of 2020, initial geographic differences in testing rates had closed substantially. Case fatality ratios were higher in non-Hispanic Black and Hispanic/Latino populations in Illinois relative to non-Hispanic White populations, suggesting that tests were insufficient to accurately capture the true burden of COVID-19 disease in the minority populations during the initial epidemic wave. While testing disparities decreased during 2020, Hispanic/Latino populations consistently remained the least tested at 1.87 tests per 1000 population per day compared with 2.58 and 2.87 for non-Hispanic Black and non-Hispanic White populations, respectively, at the end of 2020. Despite a large expansion in testing since the beginning of the first wave of the epidemic, we estimated that over half (50-80%) of all SARS-CoV-2 infections were not detected by diagnostic testing and continued to evade surveillance.

conclusionsSystematic methods for identifying relatively under-tested geographic regions and demographic groups may enable policymakers to regularly monitor and evaluate the shifting landscape of diagnostic testing, allowing officials to prioritize allocation of testing resources to reduce disparities in COVID-19 burden and eventually reduce SARS-CoV-2 transmission.

Indexed as

COVID-19SARS-CoV-2COVID-19 TestingHumansIllinoisPandemicsUnited StatesCase fatality rateCOVID-19Diagnostic testingIllinoisInfection fatality rateRacial disparitiesSARS-CoV-2

Identifiers

PMID34107947
PMCPMC8189821
OpenAlexW3170169406

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.