ArticleBMC pediatrics2021
Prevalence of increased transaminases and its association with sex, age, and metabolic parameters in children and adolescents with obesity - a nationwide cross-sectional cohort study.
Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Metabolic Risk Factors Are Associated With Weight Status Change Over Four Years in Children Aged 4-6 Years With Obesity.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Pancreatic steatosis is associated with exocrine pancreatic dysfunction in children with MASLD: a prospective cross-sectional study.BMC pediatrics · 2026Article
- Age-stratified association between AST/ALT ratio and all-cause mortality in asthma patients: a retrospective cohort study from the NHANES database.BMC pulmonary medicine · 2026Article
- Liver Injury Biomarkers in Pediatric Metabolic Syndrome: Key Biochemical Associations.Metabolites · 2026Article
- Potential alternative and novel biomarkers for paediatric MAFLD: exploratory evidence from a Chinese cohort.BMC gastroenterology · 2025Article
- The evolving landscape of pediatric obesity and metabolic dysfunction-associated steatotic liver disease.Frontiers in pediatrics · 2025Review
- Obesity and Outcomes of Kawasaki Disease and COVID-19-Related Multisystem Inflammatory Syndrome in Children.JAMA network open · 2023Article
- Laboratory Findings in Children with Excess Body Weight in Romania.Medicina (Kaunas, Lithuania) · 2023Article
- Prevalence and associated factors of metabolic-associated fatty liver disease in overweight Finnish children and adolescents.Frontiers in endocrinology · 2023Article
- Pediatric obesity-Long-term consequences and effect of weight loss.Journal of internal medicine · 2022Review
- Effects ofFrontiers in public health · 2022Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundChildhood obesity increases the risk of non-alcoholic fatty liver disease marked by elevated alanine aminotransferase (ALT). This study investigated the prevalence of increased ALT in children and adolescents with obesity, and its associations with sex, age, degree of obesity, and metabolic parameters.
methodsIndividuals between 5 and 17.99 years of age enrolled in the Swedish Childhood Obesity Treatment Register (BORIS) before March 2020 were included. Mildly increased ALT was defined by ALT 27-51 U/L (males) and 23-43 U/L (females), while markedly increased ALT by levels above. Multiple logistic regression models were used for statistical analysis.
resultsAmong 11,776 individuals (age 11.0 ± 3.3 years, 53.5% males), the prevalence of mildly and markedly increased ALT were 37.9 and 10.6%, respectively. A sex-age interaction was found, where increasing age strengthened the odds of markedly increased ALT in males (OR, 99% CI: 1.34, 1.29-1.4 for each year) while the corresponding pattern in females with was minuscule (1.09, 1.02-1.10). Compared to class I obesity, class II and III obesity had greater odds ratios for mildly increased ALT (class II obesity OR, 99% CI: 1.51, 1.35-1.70; class III obesity OR, 99% CI: 2.17, 1.66-2.61) and for markedly increased ALT (class II obesity OR, 99% CI: 1.82, 1.51-2.20; class III obesity OR, 99% CI 3.38, 2.71-4.23). Dyslipidemia was associated with both mildly and markedly increased ALT, all p < 0.001. Prevalence of impaired fasting glucose was 19.1% in normal ALT group, 20.4% in mildly increased ALT group, and 29.0% in markedly increased ALT group.
conclusionsThe risk of markedly increased ALT increased exponentially with age among boys, but not among girls. Higher degree of obesity was observed in individuals with mildly and markedly increased ALT. Further, metabolic derangements were more prevalent among individuals with mildly and markedly increased ALT.
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