ArticleEndocrinology and metabolism (Seoul, Korea)2021
Urinary Free Metanephrines for Diagnosis of Pheochromocytoma and Paraganglioma.
Article in Endocrinology and metabolism (Seoul, Korea), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 9 citations in OpenAlex.
- Pitfalls of Adrenal Washout on CT in the Adult Population: A Pictorial Review.Diagnostics (Basel, Switzerland) · 2026Review
- The role of the adrenalectomy in the management of pheochromocytoma: the experience of a Portuguese referral center.Endocrine · 2024Article
- Laparoscopic Resection of Para-Aortic Mass at the Aortic Bifurcation: An Atypical Presentation of a Tailgut Cyst.Cureus · 2024Article
- Adrenal bleeding due to pheochromocytoma - A call for algorithm.Frontiers in endocrinology · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
backgroundPheochromocytoma and paraganglioma (PPGL) is diagnosed through biochemical confirmation of excessive catecholamines in urine and plasma. Recent technological developments have allowed us to measure urinary free metanephrines; however, the diagnostic accuracy of these new methods and the diagnostic cutoff values have not been evaluated.
methodsThis is a retrospective study of 595 subjects, including 71 PPGL cases and 524 controls. PPGL was based on pathological confirmation. Subjects with no evidence of PPGL over 2 years were included in the control group.
resultsUrinary free metanephrines yielded similar area under the curve (AUC) to urinary fractionated metanephrines and plasma free metanephrines. However, urinary free normetanephrine yielded a better AUC than did urinary fractionated normetanephrine. The optimal cutoff for urinary free metanephrine and normetanephrine corrected for urinary creatinine yielded 97.2% sensitivity and 98.1% specificity.
conclusionUrinary free metanephrines are a reliable method for diagnosing PPGL in Asian populations compared with existing biochemical methods.
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