Evidence map›Paper›PMID 34107349›Full record

ReviewBrain, behavior, and immunity2021

Asthma and posttraumatic stress disorder (PTSD): Emerging links, potential models and mechanisms.

Emily Allgire, Jaclyn W McAlees, Ian P Lewkowich, Renu Sah

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Brain, behavior, and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07660107 (Clinical Trial of Oral Supplementation With Novel Mycolicibacterium), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07660107 nacompletednot on this mapstarted 2025, after this paper: background citation

Clinical Trial of Oral Supplementation With Novel Mycolicibacterium (KGA-10)

TypeinterventionalSponsorKioga Inc.Ran2025 to 2025Enrolled8ConditionsSafety, TolerabilityArmsHeat-killed Mycolicibacterium petrae KGA-10 (NeuroAlly), Placebo (microcrystalline cellulose)
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Clinical correlations with unmet social needs in critically ill children with asthma.The journal of allergy and clinical immunology. Global · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. International journal of molecular sciences · 2023
    Article
  18. Editorial: Perspectives on PTSD and its treatment.Frontiers in behavioral neuroscience · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Emily AllgireDept. of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, OH 45220, USA; Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45220, USA.
Jaclyn W McAleesDivision of Immunobiology, Children's Hospital Medical Center, Cincinnati, OH 45220, USA.
Ian P LewkowichDivision of Immunobiology, Children's Hospital Medical Center, Cincinnati, OH 45220, USA; Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45220, USA.
Renu SahDept. of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, OH 45220, USA; Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45220, USA; VA Medical Center, Cincinnati, OH 45220, USA. Electronic address: sahr@uc.edu.
Cincinnati Children's Hospital Medical Center · USCincinnati VA Medical Center · USUniversity of Cincinnati · US

Funding

PREDOCTORAL TRAINING PROGRAM IN THE NEUROSCIENCEST32NS007453 · NINDS · UNIVERSITY OF CINCINNATI · PI HERMAN, JAMES P · 1997 to 2025
$4.0M
Neuroimmune modulators of airway inflammation associated stress and fear responsesR21MH117483 · NIMH · UNIVERSITY OF CINCINNATI · PI LEWKOWICH, IAN PAUL, SAH, RENU · 2019 to 2020
$455k
NIMH NIH HHS R21 MH117483NINDS NIH HHS T32 NS007453
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) is a highly prevalent, debilitating mental health condition. A better understanding of contributory neurobiological mechanisms will lead to effective treatments, improving quality of life for patients. Given that not all trauma-exposed individuals develop PTSD, identification of pre-trauma susceptibility factors that can modulate posttraumatic outcomes is important. Recent clinical evidence supports a strong link between inflammatory conditions and PTSD. A particularly strong association has been reported between asthma and PTSD prevalence and severity. Unlike many other PTSD-comorbid inflammatory conditions, asthma often develops in children, sensitizing them to subsequent posttraumatic pathology throughout their lifetime. Currently, there is a significant need to understand the neurobiology, shared mechanisms, and inflammatory mediators that may contribute to comorbid asthma and PTSD. Here, we provide a translational perspective of asthma and PTSD risk and comorbidity, focusing on clinical associations, relevant rodent paradigms and potential mechanisms that may translate asthma-associated inflammation to PTSD development.

Indexed as

AsthmaStress Disorders, Post-TraumaticComorbidityHumansPrevalenceQuality of Life

Identifiers

PMID34107349
PMCPMC8453093
OpenAlexW3169004192

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.