Evidence map›Paper›PMID 34107340›Full record

ReviewTransplantation and cellular therapy2021

The 2020 BMT CTN Myeloma Intergroup Workshop on Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma.

Sarah A Holstein, Nizar Bahlis, P Leif Bergsagel, Manisha Bhutani, Niccolo Bolli, Carrie Brownstein, Pierre Demolis, David Foureau, Francesca Gay, Irene M Ghobrial and 13 more

Open access · greenAbstract readReview
In one paragraph

Review in Transplantation and cellular therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 18 institutions in 8 countries.

Sarah A HolsteinUniversity of Nebraska Medical Center, Omaha, Nebraska. Electronic address: sarah.holstein@unmc.edu.
Nizar BahlisUniversity of Calgary, Arnie Charbonneau Cancer Research Institute, Calgary, Alberta, Canada.
P Leif BergsagelMayo Clinic, Scottsdale, Arizona.
Manisha BhutaniLevine Cancer Institute, Charlotte, North Carolina.
Niccolo BolliDepartment of Oncology and Hemato-Oncology, University of Milan, and Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Carrie BrownsteinCellectis Inc, New York, New York.
Pierre DemolisEuropean Medicines Agency, Amsterdam, the Netherlands.
David FoureauLevine Cancer Institute, Charlotte, North Carolina.
Francesca GayUniversity of Torino, Divisione di Ematologia 1, Myeloma Unit, Azienda Ospedaliera Citta della Salute e della Scienza, Torino, Italy.
Irene M GhobrialDana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Nicole GormleyU.S. Food and Drug Administration, Silver Spring, Maryland.
Jens HillengassRoswell Park Comprehensive Cancer Center, Buffalo, New York.
Martin KaiserInstitute of Cancer Research, London, United Kingdom.
Marcela V MausMassachusetts General Hospital, Boston, Massachusetts.
J Joseph MelenhorstUniversity of Pennsylvania, Philadelphia, Pennsylvania.
Maximilian MerzRoswell Park Comprehensive Cancer Center, Buffalo, New York; Department of Medicine II, University Clinic Leipzig, Germany.
Michael O DwyerNational University of Ireland, Galway, Ireland.
Bruno PaivaClinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC number CB16/12/00369, Pamplona, Spain.
Marcelo C PasquiniMedical College of Wisconsin, Milwaukee, Wisconsin.
Nina ShahUniversity of California San Francisco, San Francisco, California.
Sandy W WongUniversity of California San Francisco, San Francisco, California.
Saad Z UsmaniLevine Cancer Institute, Charlotte, North Carolina.
Philip L McCarthyRoswell Park Comprehensive Cancer Center, Buffalo, New York.
Levine Cancer Institute · USRoswell Park Comprehensive Cancer Center · USUniversity of California, San Francisco · USAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITCellectis (United States) · USEuropean Medicines Agency · NLFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHarvard University · USInstitute of Cancer Research · GBMassachusetts General Hospital · USMayo Clinic in Arizona · USMedical College of Wisconsin · USNavarre Institute of Health Research · ESOllscoil na Gaillimhe – University of Galway · IEUnited States Food and Drug Administration · USUniversity of Calgary · CAUniversity of Nebraska Medical Center · USUniversity of Pennsylvania · US

Funding

Blood and Marrow Transplant Clinical Trials Network DCC- The Medical College of Wisconsin, Inc.U24HL138660 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Steven M. DeVine, Mehdi Hussain Hamadani · 2017 to 2026
$71.4M
Easy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8M
MSKCC BMT CTN RenewalUG1HL069315 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI MIGUEL-ANGEL PERALES · 2017 to 2026
$2.2M
NHLBI NIH HHS U10 HL069294NHLBI NIH HHS U24 HL138660NHLBI NIH HHS UG1 HL069315
6 · The paper itself

Abstract

The fifth annual Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma was conducted as one of the American Society of Hematology Annual Meeting Scientific Workshops on Thursday December 3, 2020. This workshop focused on four main topics: (1) integrating minimal residual disease into clinical trial design and practice; (2) the molecular and immunobiology of disease evolution and progression in myeloma; (3) adaptation of next-generation sequencing, next-generation flow cytometry, and cytometry by time of flight techniques; and (4) chimeric antigen receptor T-cell and other cellular therapies for myeloma. In this report, we provide a summary of the workshop presentations and discuss future directions in the field.

Indexed as

Multiple MyelomaBone MarrowDiterpenesHigh-Throughput Nucleotide SequencingHumansNeoplasm, ResidualDiterpenesCAR T-cellCellular therapyEndpointImmune profilingMinimal residual diseaseMultiple myeloma

Identifiers

PMID34107340
PMCPMC8478786
OpenAlexW3169873720

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.