Evidence map›Paper›PMID 34107025›Full record

ArticleThe Journal of infectious diseases2021

Proper Assignation of Reactivation in a COVID-19 Recurrence Initially Interpreted as a Reinfection.

Laura Pérez-Lago, Helena Martínez-Lozano, Jose Antonio Pajares Díaz, Arantxa Díaz Gómez, Marina Machado, Pedro J Sola-Campoy, Marta Herranz, Sergio Buenestado-Serrano, Maricela Valerio, María Olmedo and 7 more

Abstract readCase Reports
In one paragraph

Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Laura Pérez-LagoServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Helena Martínez-LozanoInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Jose Antonio Pajares DíazInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Arantxa Díaz GómezInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Marina MachadoServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Pedro J Sola-CampoyServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Marta HerranzServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Sergio Buenestado-SerranoServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Maricela ValerioServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
María OlmedoServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Cristina Andrés ZayasInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Iñaki ComasInstituto de Biomedicina de Valencia-Consejo Superior de Investigaciones Científicas, Valencia, Spain.ORCID 0000-0001-5504-9408
Fernando González CandelasConsorcio Centro de Investigación Biomédica en Red Salud Pública, Spain.
Rafael BañaresInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Pilar CatalánServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.
Patricia MuñozServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.ORCID 0000-0001-5706-5583
Darío García de ViedmaServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.

Funding

Consejo Superior de Investigaciones CientíficasInstituto de Salud Carlos III COV20/00140Miguel Servet CP15/00075
6 · The paper itself

Abstract

A 77-year-old man (case R) with previous diagnosis of a mild COVID-19 episode was hospitalized 35 days later. On day 23 postadmission, he developed a second COVID-19 episode, now severe, and finally died. Initially, case R's COVID-19 recurrence was interpreted as a reinfection due to the exposure to a SARS-CoV-2 RT-PCR-positive roommate. However, whole-genome sequencing indicated that case R's recurrence corresponded to a reactivation of the strain involved in his first episode. Case R's reactivation had major consequences, leading to a more severe episode, and causing subsequent transmission to another 2 hospitalized patients, 1 of them with fatal outcome.

Indexed as

AgedAntibodies, ViralCOVID-19HumansMaleRecurrenceReinfectionSARS-CoV-2Whole Genome SequencingAntibodies, ViralCOVID-19nosocomial transmissionreactivationSARS-CoV-2WGS

Identifiers

PMID34107025
PMCPMC8394833

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.