Evidence map›Paper›PMID 34106932›Full record

ArticlePloS one2021

The estimated hepatitis C seroprevalence and key population sizes in San Diego in 2018.

Adriane Wynn, Samantha Tweeten, Eric McDonald, Wilma Wooten, Kimberley Lucas, Cassandra L Cyr, Maricris Hernandez, Franchesca Ramirez, Corey VanWormer, Scott Suckow and 2 more

Abstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Adriane WynnDivision of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA, United States of America.ORCID 0000-0001-8067-3616
Samantha TweetenSan Diego County Health and Human Services Agency, San Diego, CA, United States of America.
Eric McDonaldSan Diego County Health and Human Services Agency, San Diego, CA, United States of America.
Wilma WootenSan Diego County Health and Human Services Agency, San Diego, CA, United States of America.
Kimberley LucasCalifornia Correctional Health Care Services, San Diego, CA, United States of America.
Cassandra L CyrDivision of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA, United States of America.
Maricris HernandezDivision of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA, United States of America.
Franchesca RamirezRady Children's Hospital San Diego, San Diego, CA, United States of America.
Corey VanWormerSan Diego Blood Bank, San Diego, CA, United States of America.
Scott SuckowAmerican Liver Foundation Pacific Coast Division.
Christian B RamersLaura Rodriguez Research Institute, Family Health Centers of San Diego, San Diego, CA, United States of America.
Natasha K MartinDivision of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA, United States of America.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
Training Program in Substance Use, HIV and Related InfectionsT32DA023356 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Natasha Martin, Steffanie A Strathdee · 2007 to 2026
$7.8M
Optimizing HIV prevention portfolios targeting people who inject drugs using dynamic economic modelingR01AI147490 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARTIN, NATASHA · 2019 to 2022
$2.3M
Modeling reductions in harmful alcohol use on HIV transmission and mortality in the era of universal test and treat in UgandaK01AA027733 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WYNN, ADRIANE MICHELLE · 2020 to 2024
$888k
NCATS NIH HHS UL1 TR001442NIAAA NIH HHS K01 AA027733NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI147490NIDA NIH HHS T32 DA023356
6 · The paper itself

Abstract

backgroundThe Eliminate Hepatitis C San Diego County Initiative was established to provide a roadmap to reduce new HCV infections by 80% and HCV-related deaths by 65% by 2030. An estimate of the burden of HCV infections in San Diego County is necessary to inform planning and evaluation efforts. Our analysis was designed to estimate the HCV burden in San Diego County in 2018.

methodsWe synthesized data from the American Community Survey, Centers for Disease Control and Prevention, California Department of Public Health, Public Health Branch of California Correctional Health Care Services, San Diego Blood Bank, and published literature. Burden estimates were stratified by subgroup (people who inject drugs in the community [PWID], men who have sex with men in the community [MSM], general population in the community [stratified by age and sex], and incarcerated individuals). To account for parameter uncertainty, 100,000 parameter sets were sampled from each parameter's uncertainty distribution, and used to calculate the mean and 95% confidence interval estimates of the number of HCV seropositive adults in San Diego in 2018.

findingsWe found there were 55,354 (95% CI: 25,411-93,329) adults with a history of HCV infection in San Diego County in 2018, corresponding to an HCV seroprevalence of 2.1% (95% CI: 1.1-3.4%). Over 40% of HCV infections were among the general population aged 55-74 and one-third were among PWID.

conclusionOur study found that the largest share of infections was among adults aged 55-74, indicating the importance of surveillance, prevention, testing, and linkages to care in this group to reduce mortality. Further, programs prioritizing PWID for increased HCV testing and linkage to care are important for reducing new HCV infections.

Indexed as

AdolescentAdultAgedAge FactorsCaliforniaFemaleHepatitis CHomosexuality, MaleHumansMaleMiddle AgedPrisonersRisk FactorsSeroepidemiologic StudiesSex FactorsSubstance Abuse, Intravenous

Identifiers

PMID34106932
PMCPMC8189442

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.