Evidence map›Paper›PMID 34106877›Full record

ArticleAging2021

Identification of a nomogram based on an 8-lncRNA signature as a novel diagnostic biomarker for childhood acute lymphoblastic leukemia.

Zhang Chen, Fan Yang, Hui Liu, Fan Fan, Yanggang Lin, Jinhua Zhou, Yun Cai, Xiaoxiao Zhang, Yingxin Wu, Rui Mao and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Zhang ChenAffiliated Hospital of Southwest Jiaotong University, Chengdu 610036, China.
Fan YangEmergency Department, Peking University Third Hospital, Peking University School of Medicine, Beijing 100083, China.
Hui LiuDepartment of Neurology, General Hospital of Western Theater Command, Chengdu 610500, China.
Fan FanDepartment of Neurology, General Hospital of Western Theater Command, Chengdu 610500, China.
Yanggang LinAffiliated Hospital of Southwest Jiaotong University, Chengdu 610036, China.
Jinhua ZhouAffiliated Hospital of Southwest Jiaotong University, Chengdu 610036, China.
Yun CaiDepartment of Orthopedics, General Hospital of Western Theater Command, Chengdu 610083, China.
Xiaoxiao ZhangWest China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Yingxin WuCenter of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University and The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu 610031, China.
Rui MaoAffiliated Hospital of Southwest Jiaotong University, Chengdu 610036, China.
Tongtong ZhangMedical Research Center, The Third People's Hospital of Chengdu, The Second Chengdu Hospital Affiliated to Chongqing Medical University, Chengdu 610031, China.
Chengdu Third People's Hospital · CNSouthwest Jiaotong University · CNPeking University Third Hospital · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Childhood acute lymphoblastic leukemia (cALL) still represents a major cause of disease-related death in children. This study aimed to explore the prognostic value of long non-coding RNAs (lncRNAs) in cALL. We downloaded lncRNA expression profiles from the TARGET and GEO databases. Univariate, least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analyses were applied to identify lncRNA-based signatures. We identified an eight-lncRNA signature (LINC00630, HDAC2-AS2, LINC01278, AL356599.1, AC114490.1, AL132639.3, FUT8.AS1, and TTC28.AS1), which separated the patients into two groups with significantly different overall survival rates. A nomogram based on the signature, BCR ABL1 status and white blood cell count at diagnosis was developed and showed good accuracy for predicting the 3-, 5- and 7-year survival probability of cALL patients. The C-index values of the nomogram in the training and internal validation set reached 0.8 (95% CI, 0.757 to 0.843) and 0.806 (95% CI, 0.728 to 0.884), respectively. The nomogram proposed in this study objectively and accurately predicted the prognosis of cALL.

Indexed as

Gene Expression ProfilingGene Expression Regulation, LeukemicNomogramsAdultApoptosisBiomarkers, TumorCell Line, TumorChildDatabases, GeneticFemaleGene Regulatory NetworksHumansMaleMolecular Sequence AnnotationMultivariate AnalysisPrecursor Cell Lymphoblastic Leukemia-LymphomaBiomarkers, TumorRNA, Long Noncodingchildhood acute lymphoblastic leukemiahsa-miR-500bLINC01278nomogramprognosis

Identifiers

PMID34106877
PMCPMC8221355
OpenAlexW3169347511

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.