Evidence map›Paper›PMID 34106748›Full record

ArticleJournal of virology2021

Yasuhiro Hayashi, Kiyoto Tsuchiya, Mizuki Yamamoto, Yoko Nemoto-Sasaki, Kazunari Tanigawa, Kotaro Hama, Yusuke Ueda, Takashi Tanikawa, Jin Gohda, Kenji Maeda and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Yasuhiro HayashiFaculty of Pharma-Science, Teikyo Universitygrid.264706.1, Tokyo, Japan.
Kiyoto TsuchiyaAIDS Clinical Center, National Center for Global Health and Medicine Hospital, Tokyo, Japan.
Mizuki YamamotoResearch Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yoko Nemoto-SasakiFaculty of Pharma-Science, Teikyo Universitygrid.264706.1, Tokyo, Japan.
Kazunari TanigawaFaculty of Pharma-Science, Teikyo Universitygrid.264706.1, Tokyo, Japan.
Kotaro HamaFaculty of Pharma-Science, Teikyo Universitygrid.264706.1, Tokyo, Japan.
Yusuke UedaFaculty of Pharma-Science, Teikyo Universitygrid.264706.1, Tokyo, Japan.
Takashi TanikawaFaculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan.
Jin GohdaResearch Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Kenji MaedaDepartment of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
Jun-Ichiro InoueSenior Professor Office, The University of Tokyo, Tokyo, Japan.
Atsushi YamashitaFaculty of Pharma-Science, Teikyo Universitygrid.264706.1, Tokyo, Japan.
Teikyo University · JPNational Center for Global Health and Medicine · JPNational Institute of Infectious Diseases · JPJosai University · JPThe University of Tokyo · JP

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 18K06635
6 · The paper itself

Abstract

The membrane fusion between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and host cells is essential for the initial step of infection; therefore, the host cell membrane components, including sphingolipids, influence the viral infection. We assessed several inhibitors of the enzymes pertaining to sphingolipid metabolism, against SARS-CoV-2 spike protein (S)-mediated cell-cell fusion and viral infection.

Indexed as

Cell FusionCell MembraneFenretinideGene Knockout TechniquesHEK293 CellsHumansMembrane FluidityOxidoreductasesSARS-CoV-2Spike Glycoprotein, Coronavirusdihydroceramide desaturaseFenretinideOxidoreductasesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2antiviral agentsSARS-CoV-2sphingolipid

Identifiers

PMID34106748
PMCPMC8354230
OpenAlexW3169369484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.