Evidence map›Paper›PMID 34106705›Full record

ArticleJournal of proteome research2021

Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in

Nalini R Rao, Jeffrey N Savas

Open access · greenAbstract read
In one paragraph

Article in Journal of proteome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Excitation-inhibition homeostasis in Alzheimer's disease: a selective multiscale review of mechanisms, sex differences, and therapeutic opportunities.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  4. Article
  5. A novel, rapidly progressive ataxia due to a spontaneous Myo5a mutation in mice impairs transport proteins and alters mitochondria.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nalini R RaoDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Jeffrey N SavasDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.ORCID 0000-0001-6727-2439
Northwestern University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
Structural characterization of A-beta strain variation in AD mouse modelsR01AG061865 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LANGEN, RALF, SIEMER, ANSGAR B · 2018 to 2022
$4.2M
The role of activity induced exosome signaling in synaptic pathology of Alzheimer's DiseaseR01AG061787 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SAVAS, JEFFREY NICHOLAS · 2018 to 2022
$2.3M
Defining The Impaired Proteostasis Network in ALS Patient Motor NeuronsR21NS107761 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KISKINIS, EVANGELOS, SAVAS, JEFFREY NICHOLAS · 2018 to 2019
$435k
NCI NIH HHS P30 CA060553NIA NIH HHS R01 AG061787NIA NIH HHS R01 AG061865NINDS NIH HHS R21 NS107761
6 · The paper itself

Abstract

Toxic amyloid-beta (Aβ) peptides, produced by sequential proteolytic cleavage of the amyloid precursor protein (APP), play a key role in the initial stage of Alzheimer's disease (AD). Increasing evidence indicates that Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAnimalsDisease Models, AnimalEndocytosisHumansLevetiracetamMiceMice, TransgenicProteomicsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesLevetiracetamAlzheimer’s diseaseamyloid precursor proteinAPP knock-inaxon terminallevetiracetamquantitative proteomics

Identifiers

PMID34106705
PMCPMC8256815
OpenAlexW3170693266

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.