ArticleHuman brain mapping2021
Characterizing white matter alterations subject to clinical laterality in drug-naïve de novo Parkinson's disease.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Early functional network alterations predict motor and cognitive decline in parkinson's disease.Scientific reports · 2025Article
- Diffusion-tensor MRI study of the relationship between glymphatic system asymmetry and onset lateralization in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Gene expression asymmetry in Parkinson's disease: variation ofFrontiers in molecular neuroscience · 2025Article
- Atrophy-related corticospinal changes in advanced Parkinson's disease are associated with the genetic etiology of the disease.Journal of Parkinson's disease · 2024Article
- A population-averaged structural connectomic brain atlas dataset from 422 HCP-aging subjects.Data in brief · 2023Article
- White and gray matter alterations in de novo PD patients: which matter most?Journal of neurology · 2023Article
- Review
- Voxel-based diktiometry: Combining convolutional neural networks with voxel-based analysis and its application in diffusion tensor imaging for Parkinson's disease.Human brain mapping · 2022Article
- Fixel based analysis of white matter alterations in early stage cerebral small vessel disease.Scientific reports · 2022Article
- Recent advances in using diffusion tensor imaging to study white matter alterations in Parkinson's disease: A mini review.Frontiers in aging neuroscience · 2022Review
- Characterizing white matter alterations subject to clinical laterality in drug-naïve de novo Parkinson's disease.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized by a range of motor and nonmotor symptoms, often with the motor dysfunction initiated unilaterally. Knowledge regarding disease-related alterations in white matter pathways can effectively help improve the understanding of the disease and propose targeted treatment strategies. Microstructural imaging techniques, including diffusion tensor imaging (DTI), allows inspection of white matter integrity to study the pathogenesis of various neurological conditions. Previous voxel-based analyses with DTI measures, such as fractional anisotropy and mean diffusivity have uncovered changes in brain regions that are associated with PD, but the conclusions were inconsistent, partially due to small patient cohorts and the lack of consideration for clinical laterality onset, particularly in early PD. Fixel-based analysis (FBA) is a recent framework that offers tract-specific insights regarding white matter health, but very few FBA studies on PD exist. We present a study that reveals strengthened and weakened white matter integrity that is subject to symptom laterality in a large drug-naïve de novo PD cohort using complementary DTI and FBA measures. The findings suggest that the disease gives rise to tissue degeneration and potential re-organization in the early stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.