Evidence map›Paper›PMID 34106458›Full record

Trial reportEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2021

Development of dental caries and risk factors between 1 and 7 years of age in areas of high risk for dental caries in Stockholm, Sweden.

M Anderson, G Dahllöf, A Warnqvist, M Grindefjord

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06957509 (Salivary Metaproteome as a Prediction Tool in Early Childhood Caries), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06957509 recruitingnot on this mapstarted 2025, after this paper: background citation

Salivary Metaproteome as a Prediction Tool in Early Childhood Caries

TypeobservationalSponsorKarolinska InstitutetRan2025 to 2027Enrolled100ConditionsEarly Childhood Caries (ECC)
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. OXIS Contacts and Approximal Caries in 3-6-year-old Children: A Prospective Cohort Study.International journal of clinical pediatric dentistry · 2025
    Article
  4. Article
  5. Observational
  6. Integrating oral and social factors in individual caries risk assessments in preschool children-a registry-based study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

M AndersonDivision of Orthodontics and Pediatric Dentistry, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden. maria.anderson@sll.se.ORCID http://orcid.org/0000-0003-2765-5931
G DahllöfDivision of Orthodontics and Pediatric Dentistry, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-8536-5292
A WarnqvistDivision of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-5691-2127
M GrindefjordDivision of Orthodontics and Pediatric Dentistry, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-6693-4602
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo explore caries predictors at age 1 year and caries development at ages 5 and 7 years in two groups of children following different fluoride-based preventive programs.

methodsWe conducted a prospective cluster-randomized controlled intervention trial with two parallel arms comparing two prevention programs: one program included fluoride varnish applications every 6 months, the other did not; otherwise, the programs were the same. Participants were 1- and 3-year-old children enrolled at 23 dental clinics in high-risk areas in Stockholm, Sweden. The baseline examination included structured interviews. Caries data were extracted from dental records. The primary outcome measures were ICDAS 1-6 > 0 at baseline (age 1 year) and defs > 0 at ages 2, 3, 5, and 7 years. The secondary outcome measure at age 7 was DFS > 0.

resultsContinuous caries development occurred: defs > 0 in 23% at 5 years and in 42% at 7 years. We found no difference in caries development between children who had or had not received fluoride varnish as toddlers. At age 1-year, significant predictors for dental caries in later preschool years were immigrant background, family income, and sweets consumption. Fluoride toothpaste > once a day at 1 year had an OR < 1 for defs > 0 at 5- and 7 years.

conclusionsFor toddlers, fluoride varnish does not seem to be an adequate prevention tool. Brushing with fluoride toothpaste from 1 year of age could not arrest caries development. Immigrant background was the strongest predictor. A new toolbox as well as collaborative upstream actions for reducing free-sugar intake are needed.

Indexed as

Dental CariesCariostatic AgentsChildChild, PreschoolFluorides, TopicalHumansInfantProspective StudiesRisk FactorsSwedenCariostatic AgentsFluorides, TopicalEarly childhood cariesICDASPreschool childrenPreventionProgressionTopical fluoride

Identifiers

PMID34106458
PMCPMC8526475
OpenAlexW3166751087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.