Trial reportEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2021
Development of dental caries and risk factors between 1 and 7 years of age in areas of high risk for dental caries in Stockholm, Sweden.
Trial report in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06957509 (Salivary Metaproteome as a Prediction Tool in Early Childhood Caries), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Salivary Metaproteome as a Prediction Tool in Early Childhood Caries
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Impact of unhealthy food and beverage consumption on children's risk of dental caries: a systematic review.Nutrition reviews · 2024Pooled it
- Mapping the evidence on lifestyle diseases: protocol for a systematic scoping review.Systematic reviews · 2026Article
- OXIS Contacts and Approximal Caries in 3-6-year-old Children: A Prospective Cohort Study.International journal of clinical pediatric dentistry · 2025Article
- Student Assessments of Early Childhood Caries in Some Informal Settlements of Cape Town: A 10-Year Series of Cross-Sectional Studies.Public health challenges · 2025Article
- Sociodemographic and clinical factors associated with early childhood caries in Peruvian pre-schoolers.BMC oral health · 2025Observational
- Integrating oral and social factors in individual caries risk assessments in preschool children-a registry-based study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
- Association between flavonoids intake and dental caries in children and adolescents: a cross-sectional study from the NHANES database.BMC oral health · 2024Article
- Prevalence of dental carries and its association with breastfeeding duration among young children in Addis Ababa, Ethiopia.BMC public health · 2024Article
- Nutritional factors associated with early childhood caries: A systematic review andThe Saudi dental journal · 2024Review
- Variations in Primary Molar Contact and Approximal Caries in Children: A Three-Year Prospective Cohort Study.Pediatric dentistry · 2023Article
- Caries Experience in Primary and Permanent Dentition in Children Up to 15 Years of Age from Bosnia and Herzegovina-A Retrospective Study.Children (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo explore caries predictors at age 1 year and caries development at ages 5 and 7 years in two groups of children following different fluoride-based preventive programs.
methodsWe conducted a prospective cluster-randomized controlled intervention trial with two parallel arms comparing two prevention programs: one program included fluoride varnish applications every 6 months, the other did not; otherwise, the programs were the same. Participants were 1- and 3-year-old children enrolled at 23 dental clinics in high-risk areas in Stockholm, Sweden. The baseline examination included structured interviews. Caries data were extracted from dental records. The primary outcome measures were ICDAS 1-6 > 0 at baseline (age 1 year) and defs > 0 at ages 2, 3, 5, and 7 years. The secondary outcome measure at age 7 was DFS > 0.
resultsContinuous caries development occurred: defs > 0 in 23% at 5 years and in 42% at 7 years. We found no difference in caries development between children who had or had not received fluoride varnish as toddlers. At age 1-year, significant predictors for dental caries in later preschool years were immigrant background, family income, and sweets consumption. Fluoride toothpaste > once a day at 1 year had an OR < 1 for defs > 0 at 5- and 7 years.
conclusionsFor toddlers, fluoride varnish does not seem to be an adequate prevention tool. Brushing with fluoride toothpaste from 1 year of age could not arrest caries development. Immigrant background was the strongest predictor. A new toolbox as well as collaborative upstream actions for reducing free-sugar intake are needed.
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