Evidence map›Paper›PMID 34106422›Full record

ArticleForensic science, medicine, and pathology2021

Autopsy case of fatal hypoglycemia following ingestion of a therapeutic dose of tramadol.

Kosho Yoshida, Hiroaki Sato, Toshiko Tanaka, Kentaro Kasai

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Forensic science, medicine, and pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kosho YoshidaDepartment of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Iseigaoka 1-1, Yahatanishi, Kitakyushu, Japan. k-yoshida@med.uoeh-u.ac.jp.
Hiroaki SatoDepartment of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Iseigaoka 1-1, Yahatanishi, Kitakyushu, Japan.
Toshiko TanakaDepartment of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Iseigaoka 1-1, Yahatanishi, Kitakyushu, Japan.
Kentaro KasaiDepartment of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Iseigaoka 1-1, Yahatanishi, Kitakyushu, Japan.
University of Occupational and Environmental Health Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 86-year-old female was found unconscious the day after taking a prescribed tablet containing a combination of tramadol and acetaminophen. At admission to the hospital, marked hypoglycemia (blood glucose: 4 mg/dL) was confirmed, but serum insulin and C-peptide were within the normal range, which suggested that neither endogenous hyperinsulinemia nor exogenous insulin administration was responsible for the hypoglycemia. Despite resuscitation efforts, the woman subsequently died. At autopsy, there was renal disorder, but any pathological abnormalities that could have caused hypoglycemia were not observed. Blood tramadol and acetaminophen were in the therapeutic range. We speculate that the cause of fatal hypoglycemia was tramadol intake at the therapeutic dose. Older age and renal insufficiency are factors that could have potentially caused the fatal hypoglycemia in this case despite tramadol having been taken at a therapeutic dose. This is the first case report of fatal hypoglycemia following ingestion of a therapeutic dose of tramadol.

Indexed as

HypoglycemiaTramadolAged, 80 and overAnalgesics, OpioidAutopsyEatingFemaleHumansAnalgesics, OpioidTramadolHypoglycemiaRenal insufficiencyTherapeutic doseTramadol

Identifiers

PMID34106422
OpenAlexW3171045413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.