Evidence map›Paper›PMID 34106421›Full record

ArticleAging clinical and experimental research2022

Comorbidity and the association with 1-year mortality in hip fracture patients: can the ASA score and the Charlson Comorbidity Index be used interchangeably?

Stina Ek, Anna C Meyer, Margareta Hedström, Karin Modig

Open access · hybridAbstract read
In one paragraph

Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

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  4. Factors associated with early follow-up attendance after geriatric hip fracture surgery.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026
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  11. Surgical timing and clinical factor predicting in-hospital mortality in older adults with hip fractures: a neuronal network analysis.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025
    Observational
  12. Frailty as a determinant of mortality, surgical timing and hospital stay in proximal femur fractures: a retrospective cohort study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025
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  14. Risk factors associated with 1-year mortality after osteoporotic hip fracture in Hawai'i: higher mortality risk among Native Hawaiians and other Pacific Islanders.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
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  20. Comorbidity and risk of infection among patients with hip fracture: a Danish population-based cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Stina EkUnit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. stina.ek@ki.se.ORCID http://orcid.org/0000-0001-8743-8782
Anna C MeyerUnit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Margareta HedströmDepartment of Orthopedics, Karolinska University Hospital, Stockholm, Sweden.
Karin ModigUnit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SEKarolinska University Hospital · SE

Funding

Familjen Kamprads Stiftelse 20190135
6 · The paper itself

Abstract

backgroundCharlson Comorbidity Index (CCI) has been suggested to be associated with mortality in hip fracture patients, to the same extent as more expensive and time-consuming tools. However, even CCI might be too time-consuming in a clinical setting.

aimTo investigate whether the American Society of Anaesthesiologists score (ASA score), a simple grading from the anaesthesiologist's examination, is comparable with CCI in the association with 1-year mortality after a hip fracture.

methodsThe study population was patients 60 + years registered in the Swedish Hip Fracture Registry with a first-time hip fracture between 1997 and 2017 (N = 165,596). The outcome was 1-year mortality, and the exposures were ASA score and CCI. The association between comorbidity and mortality was described with Kaplan-Meier curves and analyzed with Cox proportional hazards models.

resultsThe Kaplan-Meier curves showed a stepwise increase in mortality for increasing values of both ASA and CCI. The Hazard Ratios (HRs) for the highest ASA (4-5) were 3.8 (95% Confidence Interval 3.5-4.2) for women and 3.2 (2.8-3.6) for men in the fully adjusted models. Adjusted HRs for the highest CCI (4 +) were 3.6 (3.3-3.9) for women and 2.5 (2.3-2.7) for men. Reference was the lowest score value for both tools. The correlation between the tools was moderate.

conclusionsBoth ASA and CCI show a similar stepwise association with 1-year mortality in hip fracture patients, despite measuring different factors and capturing different individuals at risk. Since the ASA score is already accessible for health care staff, it might be preferable to aid in prioritizing vulnerable hip fracture patients at risk of adverse outcomes.

Indexed as

Hip FracturesComorbidityFemaleHospital MortalityHumansMaleRetrospective StudiesRisk FactorsGeriatricInjuryNational registerOlder adults

Identifiers

PMID34106421
PMCPMC8795011
OpenAlexW3172445639

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.