ArticleJournal of community health2021
Long-Term Trends in the Epidemiology of Major Traumatic Brain Injury.
Article in Journal of community health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Diagnostic and prognostic role of serum/plasma and CSF amyloid beta peptide levels in traumatic brain injury: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Are Tai Chi and Qigong effective in the treatment of traumatic brain injury? A systematic review.BMC complementary medicine and therapies · 2024Pooled it
- Health Outcomes Following Traumatic Brain Injury: An Umbrella Review.Neuropsychology review · 2026Review
- Development of an HInternational journal of molecular sciences · 2026Article
- Mirror Effect of Parvalbumin and Connexin 43 Expression in the Acute and Subacute Phases After Penetrating Traumatic Brain Injury Reveals a Non-Canonical Interaction.Molecules (Basel, Switzerland) · 2026Article
- Applying the Canadian Head CT Criteria to Older Adults Seen in the Emergency Department After a Fall.Journal of the American Geriatrics Society · 2026Article
- Evidence-Based Interventions for Functional Restoration and Pain Management following Traumatic Brain Injury.Archives of clinical and medical case reports · 2026Article
- Nutritional Modulation of the Endogenous Antioxidant System in the Brain-Gut Axis Following Traumatic Brain Injury.Nutrients · 2025Article
- The incidence and determinants of traumatic brain injury deaths occurring outside hospital in Australia.Emergency medicine Australasia : EMA · 2025Observational
- Sex and age-related implications for preventive measures of intensive care admitted traumatic brain injury patients in Switzerland: an observational study.Langenbeck's archives of surgery · 2025Observational
- Cyclosporine A Accelerates Neurorecovery Transcriptional Trajectory in a Swine Model of Diffuse Traumatic Brain Injury.International journal of molecular sciences · 2025Article
- Consensus on the management of traumatic brain injury in older adults: Results from a Delphi study.Brain & spine · 2025Article
- Experiences with home monitoring technology in older adults with traumatic brain injury: a qualitative study.BMC geriatrics · 2024Article
- Topical application of daphnetin hydrogel for traumatic brain injury.Frontiers in neuroscience · 2024Article
- Derivation of the Falls Decision Rule to exclude intracranial bleeding without head CT in older adults who have fallen.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Observational
- The Casual Association Inference for the Chain of Falls Risk Factors-Falls-Falls Outcomes: A Mendelian Randomization Study.Healthcare (Basel, Switzerland) · 2023Article
- Are tai chi and qigong effective in the treatment of TBI? A systematic review protocol.Frontiers in aging neuroscience · 2023Article
- Mortality risk stratification in isolated severe traumatic brain injury using the revised cardiac risk index.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Caregiver Characteristics of Adults with Acute Traumatic Brain Injury in the United States and Latin America.International journal of environmental research and public health · 2022Article
- Role of Bevacizumab on Vascular Endothelial Growth Factor in Apolipoprotein E Deficient Mice after Traumatic Brain Injury.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) is a leading cause of death and disability among adults. Falls and motor vehicle collisions (MVCs) are the most common causes of TBI hospitalizations in Canada. The purpose of this study was to determine whether, at the provincial level, there have been significant changes in the injury rate and causes of major TBI. This was a retrospective cohort study of all patients in Nova Scotia who presented with major TBI (Abbreviated Injury Scale Head score ≥ 3) between 2002 and 2018. Prospectively entered data were collected from the Nova Scotia Trauma Registry. Annual injury rates were calculated based on 100,000 population (all ages) using population estimates from Statistics Canada. Linear regression was performed to analyze annual trends of major TBI within the province. There were 5590 major TBI patients in Nova Scotia during the 16-year study period. The overall annual rate of major TBI was 37 per 100,000 population. There was a 39% increase in the rate of major TBI over the study period (r = - 0.72, R2 = 0.51, p < 0.002). Patients had a mean age of 51 ± 25 years; 72% were male. The proportion of TBIs in males decreased significantly from 76% in 2002 to 69% in 2017 (p < 0.001). Mechanisms of injury were predominantly falls (45%) and MVCs (29%); the proportion of violent injuries was 11.5%. The rate of fall-related TBIs more than doubled between 2002 and 2017, increasing from 9.1 to 20.5 injuries per 100,000 (p < 0.001). Our findings demonstrate an increasing incidence of major TBI over a 16-year period with a greater than two-fold increase in the rate of fall-related TBI. These results are important for targeting TBI prevention efforts in reducing falls, especially in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.