Evidence map›Paper›PMID 34106027›Full record

Trial reportCOPD2021

Exploring Tai Chi Exercise and Mind-Body Breathing in Patients with COPD in a Randomized Controlled Feasibility Trial.

Kristen M Kraemer, Daniel Litrownik, Marilyn L Moy, Peter M Wayne, Douglas Beach, Elizabeth S Klings, Harry Reyes Nieva, Adlin Pinheiro, Roger B Davis, Gloria Y Yeh

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in COPD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. The Science of Tai Chi andJournal of integrative and complementary medicine · 2025
    Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Kristen M KraemerDivision of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Daniel LitrownikDivision of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Marilyn L MoyHarvard Medical School, Boston, Massachusetts, USA.
Peter M WayneOsher Center for Integrative Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Douglas BeachHarvard Medical School, Boston, Massachusetts, USA.
Elizabeth S KlingsThe Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Harry Reyes NievaHarvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-7774-2561
Adlin PinheiroDivision of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Roger B DavisDivision of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Gloria Y YehDivision of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Brigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USBoston University · USHarvard University · USUnited States Department of Veterans Affairs · US

Funding

Research Training in Complementary and Integrative MedicineT32AT000051 · NCCIH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GLORIA Y YEH · 1999 to 2026
$10.2M
Clinical and Autonomic Effects of Mind-Body Exercise in COPDR01AT005436 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI YEH, GLORIA Y · 2010 to 2014
$3.1M
Mentoring and Patient-Oriented Research in Mind-Body ExerciseK24AT009465 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GLORIA Y YEH · 2017 to 2026
$1.3M
Mentoring and research in mind-body and integrative therapiesK24AT009282 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI WAYNE, PETER MICHAEL · 2017 to 2021
$834k
NCCIH NIH HHS K24 AT009282NCCIH NIH HHS K24 AT009465NCCIH NIH HHS R01 AT005436NCCIH NIH HHS T32 AT000051
6 · The paper itself

Abstract

In this pilot feasibility randomized controlled trial, participants with moderate to severe COPD were randomized to a 12-week tai chi or MBB intervention. Participants were assessed at baseline, 12 weeks, and 24 weeks. Feasibility, as assessed by intervention adherence, was the primary outcome. We also estimated preliminary between-group differences in COPD symptoms and health-related quality of life, cognitive-emotional function, and functional status across three timepoints: baseline, 12, and 24 weeks. A total of 92 participants were randomized 2:1 to tai chi (

Indexed as

Pulmonary Disease, Chronic ObstructiveTai JiExerciseFeasibility StudiesHumansQuality of Lifefeasibility studymind-body breathingrandomized controlled trialTai chi

Identifiers

PMID34106027
PMCPMC8283813
OpenAlexW3166666643

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.