Evidence map›Paper›PMID 34105936›Full record

ArticleACS nano2021

Extraction of Viral Nucleic Acids with Carbon Nanotubes Increases SARS-CoV-2 Quantitative Reverse Transcription Polymerase Chain Reaction Detection Sensitivity.

Sanghwa Jeong, Eduardo González-Grandío, Nicole Navarro, Rebecca L Pinals, Francis Ledesma, Darwin Yang, Markita P Landry

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
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  4. WSMicromachines · 2025
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  15. Article
  16. Carbon nanotubes in COVID-19: A critical review and prospects.Colloid and interface science communications · 2022
    Review
  17. Review
  18. Review
  19. Sample-to-answer salivary miRNA testing: New frontiers in point-of-care diagnostic technologies.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sanghwa JeongDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.
Eduardo González-GrandíoDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-2059-4542
Nicole NavarroDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Rebecca L PinalsDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-5369-2317
Francis LedesmaDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-6280-1394
Darwin YangDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-6839-1955
Markita P LandryDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-5832-8522
University of California, Berkeley · USPusan National University · KRQB3 · US

Funding

Single-Molecule Imaging of Biological Trauma:Cytokine-Based Intracellular CommunicationR35GM128922 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LANDRY, MARKITA · 2019 to 2023
$2.0M
NIGMS NIH HHS R35 GM128922
6 · The paper itself

Abstract

The global SARS-CoV-2 coronavirus pandemic has led to a surging demand for rapid and efficient viral infection diagnostic tests, generating a supply shortage in diagnostic test consumables including nucleic acid extraction kits. Here, we develop a modular method for high-yield extraction of viral single-stranded nucleic acids by using "capture" ssDNA sequences attached to carbon nanotubes. Target SARS-CoV-2 viral RNA can be captured by ssDNA-nanotube constructs

Indexed as

COVID-19Nanotubes, CarbonNucleic AcidsHumansReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionReverse TranscriptionRNA, ViralSARS-CoV-2Sensitivity and SpecificityNanotubes, CarbonNucleic AcidsRNA, Viralcarbon nanotubesDNA/RNA extractionnanosensorsnanotechnologyqPCRviral diagnostics

Identifiers

PMID34105936
PMCPMC8204751
OpenAlexW3171156139

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.