Evidence map›Paper›PMID 34105881›Full record

Trial reportJournal of biophotonics2021

Cross-polarization optical coherence tomographic assessment of in situ simulated erosive tooth wear.

Maria Jacinta Rosario H Romero, Savio J C Bezerra, Daniel Fried, Vincent Yang, Frank Lippert, George J Eckert, Domenick T Zero, Anderson Takeo Hara

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of biophotonics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Validation of clinically related aging models based on enamel wear.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Maria Jacinta Rosario H RomeroDepartment of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, Indiana, USA.
Savio J C BezerraDepartment of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, Indiana, USA.
Daniel FriedDepartment of Preventive and Restorative Dental Sciences, University of California San Francisco School of Dentistry, San Francisco, California, USA.ORCID 0000-0002-5327-2558
Vincent YangDepartment of Preventive and Restorative Dental Sciences, University of California San Francisco School of Dentistry, San Francisco, California, USA.
Frank LippertDepartment of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, Indiana, USA.
George J EckertDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Domenick T ZeroDepartment of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, Indiana, USA.
Anderson Takeo HaraDepartment of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, Indiana, USA.ORCID 0000-0001-9822-6064
Indiana University Health · USUniversity of California, San Francisco · USIndiana University – Purdue University Indianapolis · USIndiana University School of MedicineUniversidade de São Paulo · BR

Funding

Objective Outcome Measures for the Clinical Assessment of Erosive Tooth WearR21DE026844 · NIDCR · INDIANA UNIVERSITY INDIANAPOLIS · PI HARA, ANDERSON TAKEO · 2018 to 2019
$445k
NIDCR NIH HHS R21 DE026844NIDCR NIH HHS R21DE026844
6 · The paper itself

Abstract

This clinical study tested cross-polarization optical coherence tomography (CP-OCT) monitoring of erosive tooth wear (ETW). Twenty participants completed a 14-day/arm, 3-arm crossover study simulating different ETW severities. Participants received two enamel specimens (per arm) and were randomized to: severe (s-ETW, lemon juice/pH:2.5/4.25%wt/vol citric acid), moderate (m-ETW, grapefruit juice/pH:3.5/1.03%wt/vol citric acid), and non-ETW (water). Enamel thickness was measured with CP-OCT (day[D] 0, 7, 14) and micro-computed tomography (μ-CT; D14). Enamel surface loss was determined with CP-OCT and optical profilometry (OP; D7, D14). CP-OCT showed higher enamel surface loss for D14 than D7 for m-ETW (P = .009) and s-ETW (P = .040) and differentiated severity at D14 (s-ETW > non-ETW, P = .027). OP was able to differentiate surface loss between days (D7 < D14, P < .001) for m-ETW and s-ETW, and ETW severity effect after 7 and 14 days (non-ETW < m-ETW < s-ETW, P < .001). At D14, CP-OCT and μ-CT were positively correlated (r = .87, ICC = .62). CP-OCT showed potential as a tool for clinical ETW monitoring.

Indexed as

Tooth ErosionTooth WearCross-Over StudiesHumansTomography, Optical CoherenceX-Ray Microtomographydental erosionenamelerosive tooth wearoptical coherence tomography

Identifiers

PMID34105881
PMCPMC8448929
OpenAlexW3171769633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.