ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society2021
A novel chronic wound biofilm model sustaining coexistence of Pseudomonas aeruginosa and Staphylococcus aureus suitable for testing of antibiofilm effect of antimicrobial solutions and wound dressings.
Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Engineering in vitro models to replicate the complexity of chronic wounds.Nature communications · 2026Review
- Hyaluronic acid-based tissue-engineered biomaterials for infected diabetic foot ulcers: mechanisms, evidence, and translational challenges.Frontiers in bioengineering and biotechnology · 2026Review
- Microbial Biofilms as Barriers to Chronic Wound Healing: Diagnostic Challenges and Therapeutic Advances.Journal of clinical medicine · 2025Review
- Preparing a Dual-SpeciesMolecular pharmaceutics · 2025Article
- Catheter-Associated Urinary Tract Infections: Understanding the Interplay Between Bacterial Biofilm and Antimicrobial Resistance.International journal of molecular sciences · 2025Review
- Inactivation of Staphylococcus aureus by antimicrobial photodynamic therapy using 1,9-Dimethyl-Methylene Blue: in vitro and in vivo studies.Lasers in medical science · 2025Article
- An In Vitro Artificial Wound Slough-Biofilm Model Developed for Evaluating a Novel Antibiofilm Technology.Microorganisms · 2024Article
- Plasma activated water as a pre-treatment strategy in the context of biofilm-infected chronic wounds.Biofilm · 2023Article
- Culture Shock: An Investigation into the Tolerance of Pathogenic Biofilms to Antiseptics in Environments Resembling the Chronic Wound Milieu.International journal of molecular sciences · 2023Article
- Article
- In Vitro Models of Bacterial Biofilms: Innovative Tools to Improve Understanding and Treatment of Infections.Nanomaterials (Basel, Switzerland) · 2023Review
- Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review.Microorganisms · 2023Review
- Biofilms in Chronic Wound Infections: Innovative Antimicrobial Approaches Using the In Vitro Lubbock Chronic Wound Biofilm Model.International journal of molecular sciences · 2023Review
- Clinically relevantBiofilm · 2022Review
- Article
- 3D Biofilm Models Containing Multiple Species for Antimicrobial Testing of Wound Dressings.Microorganisms · 2022Article
- Review
- A novel chronic wound biofilm model sustaining coexistence of Pseudomonas aeruginosa and Staphylococcus aureus suitable for testing of antibiofilm effect of antimicrobial solutions and wound dressings.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic wounds are a large burden to patients and healthcare systems. Biofilm infections in chronic wounds are crucial factors leading to non-healing of wounds. It is important to study biofilm in wounds and to develop effective interventions against wound biofilm. This study presents a novel in vitro biofilm model mimicking infected chronic wounds. The novel layered chronic wound biofilm model uses woundlike media and includes both Pseudomonas aeruginosa and Staphylococcus aureus, which have been identified as the most important pathogens in wounds. The model sustains their coexistence for at least 96 h. Microscopy of the model revealed microbial growth in non-surface attached microcolonies as previously observed in vivo. The model was used to determine log
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