Evidence map›Paper›PMID 34105766›Full record

ArticleDevelopmental psychobiology2021

Socioeconomic factors, stress, hair cortisol, and white matter microstructure in children.

Katrina R Simon, Emily C Merz, Xiaofu He, Pooja M Desai, Jerrold S Meyer, Kimberly G Noble

Open access · greenAbstract read
In one paragraph

Article in Developmental psychobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Katrina R SimonTeachers College, Columbia University, New York, New York, USA.ORCID 0000-0001-8148-5035
Emily C MerzColorado State University, Fort Collins, Colorado, USA.ORCID 0000-0003-1950-2345
Xiaofu HeColumbia University Irving Medical Center, New York, New York, USA.
Pooja M DesaiTeachers College, Columbia University, New York, New York, USA.
Jerrold S MeyerUniversity of Massachusetts Amherst, Amherst, Massachusetts, USA.ORCID 0000-0002-8382-7075
Kimberly G NobleTeachers College, Columbia University, New York, New York, USA.
Columbia University · USColorado State University · USColumbia University Irving Medical Center · USUniversity of Massachusetts Amherst · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
RESEARCH TRAINING PROGRAM IN PSYCHIATRIC EPIDEMIOLOGYT32MH013043 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Katherine M. Keyes · 1985 to 2026
$11.7M
NCATS NIH HHS UL1 TR001873NCRR NIH HHS UL1 RR024156NIMH NIH HHS T32 MH013043
6 · The paper itself

Abstract

Socioeconomic disadvantage has been linked to increased stress exposure in children and adults. Exposure to stress in childhood has been associated with deleterious effects on cognitive development and well-being throughout the lifespan. Further, exposure to stress has been associated with differences in brain development in children, both in cortical and subcortical gray matter. However, less is known about the associations among socioeconomic disadvantage, stress, and children's white matter development. In this study, we investigated whether socioeconomic disparities would be associated with differences in white matter microstructure in the cingulum bundle, as has been previously reported. We additionally investigated whether any such differences could be explained by differences in stress exposure and/or physiological stress levels. White matter tracts were measured via diffusion tensor imaging in 58 children aged 5-9 years. Results indicated that greater exposure to stressful life events was associated with higher child hair cortisol concentrations. Further, physiological stress, as indexed by hair cortisol concentrations, were associated with higher fractional anisotropy in the cingulum bundle. These results have implications for better understanding how perceived and physiological stress may alter neural development during childhood.

Indexed as

HydrocortisoneWhite MatterAdultBrainChildChild, PreschoolDiffusion Tensor ImagingHairHumansSocioeconomic FactorsHydrocortisonechildcortisoldiffusion-weighted imagingneurodevelopmentsocioeconomic statusstress

Identifiers

PMID34105766
PMCPMC9153946
OpenAlexW3171140676

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.