Evidence map›Paper›PMID 34105359›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2021

Heparin-based blood purification attenuates organ injury in baboons with

Lingye Chen, Bryan D Kraft, Victor L Roggli, Zachary R Healy, Christopher W Woods, Ephraim L Tsalik, Geoffrey S Ginsburg, David M Murdoch, Hagir B Suliman, Claude A Piantadosi and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Lingye ChenDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Bryan D KraftDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina.ORCID 0000-0001-6545-8803
Victor L RoggliDepartment of Pathology, Duke University Medical Center, Durham, North Carolina.
Zachary R HealyDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Christopher W WoodsDurham Department of Veterans Affairs Medical Center, Durham, North Carolina.
Ephraim L TsalikDurham Department of Veterans Affairs Medical Center, Durham, North Carolina.
Geoffrey S GinsburgCenter for Applied Genomics & Precision Medicine, Duke University Medical Center, Durham, North Carolina.
David M MurdochDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Hagir B SulimanDepartment of Anesthesiology, Duke University Medical Center, Durham, North Carolina.
Claude A PiantadosiDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Karen E Welty-WolfDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Duke Medical Center · US

Funding

Role of S-nitrosothiols in Akt1 signaling and pneumonia resolutionK08HL130557 · NHLBI · DUKE UNIVERSITY · PI KRAFT, BRYAN D. · 2017 to 2021
$591k
Characterization of CMV-specific T cell responses in immunocompromised hostsK99AI143927 · NIAID · DUKE UNIVERSITY · PI HEALY, ZACHARY RYAN · 2020 to 2021
$248k
NHLBI NIH HHS K08 HL130557NHLBI NIH HHS L30 HL129295NIAID NIH HHS K99 AI143927NIAID NIH HHS L30 AI155399
6 · The paper itself

Abstract

Bacterial pneumonia is a major cause of morbidity and mortality worldwide despite the use of antibiotics, and novel therapies are urgently needed. Building on previous work, we aimed to

Indexed as

HemofiltrationAnimalsCytokinesHeparinMalePapioPilot ProjectsPneumonia, PneumococcalShock, SepticStreptococcus pneumoniaeCytokinesHeparinanimal disease modelsextracorporeal circulationinflammasomespathogen-associated molecular pattern moleculessepsis

Identifiers

PMID34105359
PMCPMC8410114
OpenAlexW3168224479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.