Evidence map›Paper›PMID 34105286›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Rapid and Repetitive Inactivation of SARS-CoV-2 and Human Coronavirus on Self-Disinfecting Anionic Polymers.

Bharadwaja S T Peddinti, Sierra N Downs, Jiaqi Yan, Steven D Smith, Reza A Ghiladi, Vijay Mhetar, Roger Tocchetto, Anthony Griffiths, Frank Scholle, Richard J Spontak

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Bharadwaja S T PeddintiDepartment of Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27695, USA.
Sierra N DownsNational Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, MA, 02118, USA.
Jiaqi YanDepartment of Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27695, USA.
Steven D SmithCorporate Research & Development, The Procter & Gamble Company, Cincinnati, OH, 45224, USA.
Reza A GhiladiDepartment of Chemistry, North Carolina State University, Raleigh, NC, 27695, USA.
Vijay MhetarKraton Innovation Center, Kraton Corporation, Houston, TX, 77084, USA.
Roger TocchettoKraton Innovation Center, Kraton Corporation, Houston, TX, 77084, USA.
Anthony GriffithsNational Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, MA, 02118, USA.
Frank ScholleCenter for Advanced Virus Experimentation, North Carolina State University, Raleigh, NC, 27695, USA.
Richard J SpontakDepartment of Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27695, USA.ORCID 0000-0001-8458-0038
North Carolina State University · USBoston University · USKraton (United States) · USProcter & Gamble (United States) · US

Funding

Halyard HealthKraton CorporationNC State Comparative Medicine InstituteNonwovens Institute, North Carolina State UniversitySchool of Medicine, Boston University
6 · The paper itself

Abstract

While the ongoing COVID-19 pandemic affirms an urgent global need for effective vaccines as second and third infection waves are spreading worldwide and generating new mutant virus strains, it has also revealed the importance of mitigating the transmission of SARS-CoV-2 through the introduction of restrictive social practices. Here, it is demonstrated that an architecturally- and chemically-diverse family of nanostructured anionic polymers yield a rapid and continuous disinfecting alternative to inactivate coronaviruses and prevent their transmission from contact with contaminated surfaces. Operating on a dramatic pH-drop mechanism along the polymer/pathogen interface, polymers of this archetype inactivate the SARS-CoV-2 virus, as well as a human coronavirus surrogate (HCoV-229E), to the minimum detection limit within minutes. Application of these anionic polymers to frequently touched surfaces in medical, educational, and public-transportation facilities, or personal protection equipment, can provide rapid and repetitive protection without detrimental health or environmental complications.

Indexed as

COVID-19DisinfectantsHumansPandemicsPolymersSARS-CoV-2DisinfectantsPolymersantiviral materialscharged block polymersmicrophase-ordered materialspolyanionsthermoplastic elastomers

Identifiers

PMID34105286
PMCPMC7994973
OpenAlexW3127811610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.