Evidence map›Paper›PMID 34105269›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Targeted Drug Delivery for Sustainable Crop Protection: Transport and Stability of Polymeric Nanocarriers in Plants.

Sebastian J Beckers, Alexander H J Staal, Christine Rosenauer, Mangala Srinivas, Katharina Landfester, Frederik R Wurm

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
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  4. Advancements in programmed cell death research in antitumor therapy: a comprehensive overview.Apoptosis : an international journal on programmed cell death · 2025
    Review
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  6. Article
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  10. Article
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  13. Two-dimensional ultrathin TiFrontiers in bioengineering and biotechnology · 2022
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sebastian J BeckersMax-Planck-Institut für Polymerforschung, Ackermannweg 10, Mainz, 55128, Germany.
Alexander H J StaalDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 26/28, Nijmegen, 6525GA, The Netherlands.
Christine RosenauerMax-Planck-Institut für Polymerforschung, Ackermannweg 10, Mainz, 55128, Germany.
Mangala SrinivasDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 26/28, Nijmegen, 6525GA, The Netherlands.
Katharina LandfesterMax-Planck-Institut für Polymerforschung, Ackermannweg 10, Mainz, 55128, Germany.
Frederik R WurmMax-Planck-Institut für Polymerforschung, Ackermannweg 10, Mainz, 55128, Germany.ORCID 0000-0002-6955-8489

Funding

European Union's Horizon 2020 research and innovation program 720708European Union's Horizon 2020 research and innovation program ERC-2014-StG-336454-CoNQUeSTEuropean Union's Horizon 2020 research and innovation program ERC-2015-PoC-713524-CONQUESTEuropean Union's Horizon 2020 research and innovation program ERC-2019-PoC-862089-CENYAEuropean Union's Horizon 2020 research and innovation program STW-14716
6 · The paper itself

Abstract

Spraying of agrochemicals (pesticides, fertilizers) causes environmental pollution on a million-ton scale. A sustainable alternative is target-specific, on-demand drug delivery by polymeric nanocarriers. Trunk injections of aqueous nanocarrier dispersions can overcome the biological size barriers of roots and leaves and allow distributing the nanocarriers through the plant. To date, the fate of polymeric nanocarriers inside a plant is widely unknown. Here, the in planta conditions in grapevine plants are simulated and the colloidal stability of a systematic series of nanocarriers composed of polystyrene (well-defined model) and biodegradable lignin and polylactic-co-glycolic acid by a combination of different techniques is studied. Despite the adsorption of carbohydrates and other biomolecules onto the nanocarriers' surface, they remain colloidally stable after incubation in biological fluids (wood sap), suggesting a potential transport via the xylem. The transport is tracked by fluorine- and ruthenium-labeled nanocarriers inside of grapevines by

Indexed as

Crop ProtectionDrug Delivery SystemsAgrochemicalsColloidsDrug CarriersFertilizersHumansLigninNanoparticlesNanostructuresPesticidesPlantsPolymersAgrochemicalsColloidsDrug CarriersFertilizersLigninPesticidesPolymersagrochemicaldrug deliveryminiemulsionnanocarriersplant protection

Identifiers

PMID34105269
PMCPMC8188206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.