Evidence map›Paper›PMID 34105220›Full record

ArticleAngewandte Chemie (International ed. in English)2021

On the Biology of Werner's Complex.

Raphael E F de Paiva, Erica J Peterson, Jaroslav Malina, Mary Zoepfl, J David Hampton, Wyatt E Johnson, Angelica Graminha, Amine Ourahmane, Michael A McVoy, Viktor Brabec and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Raphael E F de PaivaInstitute for Glycomics, Griffith University, Gold Coast Campus, Southport, Qld., 4222, Australia.ORCID 0000-0003-2549-0344
Erica J PetersonDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284-2006, USA.
Jaroslav MalinaInstitute of Biophysics, Czech Academy of Sciences, Kralovopolska 135, 61265, Brno, Czech Republic.
Mary ZoepflDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284-2006, USA.
J David HamptonMassey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298-0037, USA.
Wyatt E JohnsonDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284-2006, USA.
Angelica GraminhaDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284-2006, USA.
Amine OurahmaneDepartment of Pediatrics, Virginia Commonwealth University, Richmond, VA, 23298-0163, USA.
Michael A McVoyDepartment of Pediatrics, Virginia Commonwealth University, Richmond, VA, 23298-0163, USA.
Viktor BrabecInstitute of Biophysics, Czech Academy of Sciences, Kralovopolska 135, 61265, Brno, Czech Republic.
Susan J Berners-PriceInstitute for Glycomics, Griffith University, Gold Coast Campus, Southport, Qld., 4222, Australia.
Nicholas P FarrellInstitute for Glycomics, Griffith University, Gold Coast Campus, Southport, Qld., 4222, Australia.ORCID 0000-0001-7160-7182
Virginia Commonwealth University · USGriffith University · AUCzech Academy of Sciences, Institute of Biophysics · CZ

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Kim Felder Rhoads · 1985 to 2026
$51.0M
NCI NIH HHS P30 CA016059NIH HHS P30 CA016059
6 · The paper itself

Abstract

Werner's Complex, as a cationic coordination complex (CCC), has hitherto unappreciated biological properties derived from its binding affinity to highly anionic biomolecules such as glycosaminoglycans (GAGs) and nucleic acids. Competitive inhibitor and spectroscopic assays confirm the high affinity to GAGs heparin, heparan sulfate (HS), and its pentasaccharide mimetic Fondaparinux (FPX). Functional consequences of this affinity include inhibition of FPX cleavage by bacterial heparinase and mammalian heparanase enzymes with inhibition of cellular invasion and migration. Werner's Complex is a very efficient condensing agent for DNA and tRNA. In proof-of-principle for translational implications, it is demonstrated to display antiviral activity against human cytomegalovirus (HCMV) at micromolar concentrations with promising selectivity. Exploitation of non-covalent hydrogen-bonding and electrostatic interactions has motivated the unprecedented discovery of these properties, opening new avenues of research for this iconic compound.

Indexed as

Antiviral AgentsCoordination ComplexesCytomegalovirusFondaparinuxGlycosaminoglycansHumansMicrobial Sensitivity TestsAntiviral AgentsCoordination ComplexesFondaparinuxGlycosaminoglycansAntiviral efficacyBiological EffectsDNA Binding and CondensationGlycosaminoglycan interactionsWerner's Complex

Identifiers

PMID34105220
PMCPMC8464317
OpenAlexW3171587026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.