Evidence map›Paper›PMID 34105104›Full record

ArticleSleep & breathing = Schlaf & Atmung2022

Metabolic outcomes in adults with type 2 diabetes and sleep disorders.

Christopher C Imes, Zhadyra Bizhanova, Susan M Sereika, Mary T Korytkowski, Charles W Atwood, Lora E Burke, Jacob Kariuki, Jonna L Morris, Robert Stansbury, Patrick J Strollo and 1 more

Registry-linked trialOpen access · greenAbstract readComparative Study
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01901055 (The Effect of Treatment of Obstructive Sleep Apnea on Diabetes Self Management and Glycemic Control), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01901055 naterminatednot on this map

The Effect of Treatment of Obstructive Sleep Apnea on Diabetes Self Management and Glycemic Control

TypeinterventionalSponsorEileen R. ChasensRan2014 to 2019Enrolled98ConditionsType 2 Diabetes, Obstructive Sleep ApneaArmsCPAP, Sham-CPAP, Diabetes Education
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Systematic review of changes in extracellular vesicles associated with obstructive sleep apnoea: implications for diagnosis and treatment.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Pooled it
  3. Article
  4. A Structured Narrative Review of the OSA-T2DM Axis.Journal of clinical medicine · 2025
    Review
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Christopher C ImesSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. imesc@pitt.edu.ORCID 0000-0002-0666-3142
Zhadyra BizhanovaGraduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-0820-019X
Susan M SereikaSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-7840-1352
Mary T KorytkowskiDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-7131-8903
Charles W AtwoodDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Lora E BurkeSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-2434-9867
Jacob KariukiSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-2423-6029
Jonna L MorrisSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Robert StansburySchool of Medicine, West Virginia University, Morgantown, WV, USA.ORCID 0000-0002-3176-8333
Patrick J StrolloDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-2065-9641
Eileen R ChasensSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-7233-1269
University of Pittsburgh · USWest Virginia University · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
The Effect of Treatment of OSA on Diabetes Self Management and Glycemic ControlR01DK096028 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHASENS, EILEEN R · 2013 to 2017
$2.9M
NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR001857NIDDK NIH HHS R01 DK096028
6 · The paper itself

Abstract

purposeInsomnia is frequently co-morbid with obstructive sleep apnea (OSA); the effect of insomnia or co-morbid insomnia and OSA (OSA + I) on associated metabolic outcomes in adults with type 2 diabetes (T2D) remains unclear. This study in adults with T2D compared metabolic outcomes among persons with OSA, insomnia, or OSA + I.

methodsThis study analyzed baseline data from the Diabetes Sleep Treatment Trial of persons recruited for symptoms of OSA or poor sleep quality. Home sleep studies determined OSA presence and severity. Insomnia was evaluated using the Insomnia Severity Index. Height and weight to calculate body mass index (BMI) and blood for laboratory values were obtained. Multivariate general linear models were used to examine the impact of the type of sleep disorder and sociodemographic, lifestyle, and sleep risk factors on metabolic outcomes.

resultsParticipants (N = 253) were middle-aged (56.3 ± 10.5 years), white (60.5%), obese (mean BMI of 35.3 ± 7.1 kg/m

conclusionsFindings suggest that insomnia frequently co-exists with OSA, is independently associated with metabolic outcomes in adults with T2D, and should be considered in investigations of the effects of OSA in persons with T2D.

trial registrationDiabetes-Obstructive Sleep Apnea Treatment Trial (NCT01901055), https: Clinicaltrials.gov/ct2/show/NCT01901055; Registration date: July 17, 2013.

Indexed as

AgedCross-Sectional StudiesDiabetes ComplicationsDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersDiabetesInsomniaMetabolic risk factorsObstructive sleep apnea

Identifiers

PMID34105104
PMCPMC8655315
OpenAlexW3167980478

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.