Evidence map›Paper›PMID 34105014›Full record

ArticleBasic research in cardiology2021

Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice.

Jonas Gregorius, Chen Wang, Oumaima Stambouli, Tanja Hussner, Yachao Qi, Tobias Tertel, Verena Börger, Ayan Mohamud Yusuf, Nina Hagemann, Dongpei Yin and 11 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Basic research in cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 1 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 1 synthesis or guideline pooled it, 215 citations in OpenAlex.

  1. Pooled it
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  10. Stem cell extracellular vesicles for neuropsychiatric disorders and translation.Extracellular vesicles and circulating nucleic acids · 2026
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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 2 countries.

Jonas Gregorius *Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany.ORCID http://orcid.org/0000-0002-6416-8289
Chen Wang *Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany.
Oumaima StambouliInstitute of Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Virchowstraße 179, 45147, Essen, Germany.
Tanja HussnerDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany.
Yachao QiDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany.
Tobias TertelInstitute of Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Virchowstraße 179, 45147, Essen, Germany.
Verena BörgerInstitute of Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Virchowstraße 179, 45147, Essen, Germany.
Ayan Mohamud YusufDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany.
Nina HagemannDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany.
Dongpei YinDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany.
Robin DittrichInstitute of Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Virchowstraße 179, 45147, Essen, Germany.
Yanis MouloudInstitute of Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Virchowstraße 179, 45147, Essen, Germany.
Fabian D MairingerInstitute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Fouzi El MagraouiLeibniz Institute for Analytical Sciences (ISAS), Dortmund, Germany.
Aurel Popa-WagnerCenter of Experimental and Clinical Medicine, University of Medicine and Pharmacy, Craiova, Romania.
Christoph KleinschnitzDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany.
Thorsten R DoeppnerDepartment of Neurology, University Medicine Göttingen, Göttingen, Germany.
Matthias GunzerLeibniz Institute for Analytical Sciences (ISAS), Dortmund, Germany.
Helmut E MeyerLeibniz Institute for Analytical Sciences (ISAS), Dortmund, Germany.
Bernd GiebelInstitute of Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Virchowstraße 179, 45147, Essen, Germany. bernd.giebel@uk-essen.de.
Dirk M HermannDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany. dirk.hermann@uk-essen.de.
University of Duisburg-Essen · DEEssen University Hospital · DELeibniz Institute for Analytical Sciences - ISAS · DEUniversity Hospitals of the Ruhr-University of Bochum · DEUniversity of Medicine and Pharmacy of Craiova · RO

Funding

Deutsche Forschungsgemeinschaft HE3173/11-1Deutsche Forschungsgemeinschaft HE3173/12-1Deutsche Forschungsgemeinschaft HE3173/13-1ERA-NET EuroTransBio EV TrustNational Authority for Science, Research and Innovation PN-III-P2-2.1-PED-2016-1013National Authority for Science, Research and Innovation PN-III-P4-ID-PCE-2016-0215National Authority for Science, Research and Innovation PN-III-P4-ID-PCE-2016-0340National Authority for Science, Research and Innovation UEFISCDI
6 · The paper itself

Abstract

Obtained from the right cell-type, mesenchymal stromal cell (MSC)-derived small extracellular vesicles (sEVs) promote stroke recovery. Within this process, microvascular remodeling plays a central role. Herein, we evaluated the effects of MSC-sEVs on the proliferation, migration, and tube formation of human cerebral microvascular endothelial cells (hCMEC/D3) in vitro and on post-ischemic angiogenesis, brain remodeling and neurological recovery after middle cerebral artery occlusion (MCAO) in mice. In vitro, sEVs obtained from hypoxic (1% O

Indexed as

Neovascularization, PhysiologicVascular RemodelingAngiogenic ProteinsAnimalsBrainCell HypoxiaCell MovementCell ProliferationCells, CulturedDisease Models, AnimalEndothelial CellsExtracellular VesiclesHumansInfarction, Middle Cerebral ArteryMaleMesenchymal Stem CellsAngiogenic ProteinsMicroRNAsEndothelial migrationMicrovascular network characteristicsMicrovascular remodelingNeuronal survivalPolymorphonuclear neutrophilTube formation

Identifiers

PMID34105014
PMCPMC8187185
OpenAlexW3172798414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.