Evidence map›Paper›PMID 34104992›Full record

ReviewHandbook of experimental pharmacology2021

Organic Cation Transporters and Nongenomic Glucocorticoid Action.

Kelsey C Benton, Christopher A Lowry, Paul J Gasser

Abstract readReview
PubMed Publisher
In one paragraph

Review in Handbook of experimental pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Organic Cation Transporters in Psychiatric Disorders.Handbook of experimental pharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kelsey C BentonDepartment of Biomedical Sciences, Marquette University, Milwaukee, WI, USA.
Christopher A LowryDepartment of Integrative Physiology, Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Paul J GasserDepartment of Biomedical Sciences, Marquette University, Milwaukee, WI, USA. paul.gasser@marquette.edu.
Marquette University · USUniversity of Colorado Boulder · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corticosteroid hormones exert powerful influences on neuronal physiology and behavior by activating intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR), which act as ligand-gated transcription factors, altering gene expression. In addition to these genomic effects on physiology and behavior, which are usually delayed by minutes to hours, corticosteroid hormones also initiate rapid effects through diverse nongenomic mechanisms. One such mechanism involves the direct inhibition by corticosteroid hormones of monoamine transport mediated by the "uptake

Indexed as

GlucocorticoidsOrganic Cation Transport ProteinsCationsCorticosteroneHumansNeuronsCationsCorticosteroneGlucocorticoidsOrganic Cation Transport ProteinsCorticosteroneDopamineHistamineNorepinephrineOCT2OCT3Organic cation transporter 2Organic cation transporter 3Serotoninslc22a3Solute carrier family 22 (organic cation transporter)

Identifiers

PMID34104992
OpenAlexW3169956431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.