Evidence map›Paper›PMID 34104987›Full record

ArticlePsychopharmacology2021

Adaptive aspects of impulsivity and interactions with effects of catecholaminergic agents in the 5-choice serial reaction time task: implications for ADHD.

Chiara Toschi, Mona El-Sayed Hervig, Parisa Moazen, Maximilian G Parker, Jeffrey W Dalley, Ulrik Gether, Trevor W Robbins

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Chiara Toschi *Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing St., CB2 3EB, Cambridge, UK. ct452@cam.ac.uk.ORCID http://orcid.org/0000-0003-4243-2701
Mona El-Sayed Hervig *Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing St., CB2 3EB, Cambridge, UK.
Parisa MoazenDepartment of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing St., CB2 3EB, Cambridge, UK.
Maximilian G ParkerDepartment of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing St., CB2 3EB, Cambridge, UK.
Jeffrey W DalleyDepartment of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing St., CB2 3EB, Cambridge, UK.
Ulrik GetherDepartment of Neuroscience, University of Copenhagen, DK-2200, Copenhagen, Denmark.
Trevor W RobbinsDepartment of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing St., CB2 3EB, Cambridge, UK.
University of Cambridge · GBUniversity of Copenhagen · DKTarbiat Modares University · IR

Funding

Medical Research Council G1000183Wellcome TrustWellcome Trust 093875/Z/10/Z
6 · The paper itself

Abstract

backgroundWork in humans has shown that impulsivity can be advantageous in certain settings. However, evidence for so-called functional impulsivity is lacking in experimental animals.

aimsThis study investigated the contexts in which high impulsive (HI) rats show an advantage in performance compared with mid- (MI) and low impulsive (LI) rats. We also assessed the effects of dopaminergic and noradrenergic agents to investigate underlying neurotransmitter mechanisms.

methodsWe tested rats on a variable inter-trial interval (ITI) version of the 5-choice serial reaction time task (5CSRTT). Rats received systemic injections of methylphenidate (MPH, 1 mg/kg and 3 mg/kg), atomoxetine (ATO, 0.3 mg/kg and 1 mg/kg), amphetamine (AMPH, 0.2 mg/kg), the alpha-2a adrenoceptor antagonist atipamezole (ATI, 0.3 mg/kg) and the alpha-1 adrenoceptor agonist phenylephrine (PHEN, 1 mg/kg) prior to behavioural testing.

resultsUnlike LI rats, HI rats exhibited superior performance, earning more reinforcers, on short ITI trials, when the task required rapid responding. MPH, AMPH and ATI improved performance on short ITI trials and increased impulsivity in long ITI trials, recapitulating the behavioural profile of HI. In contrast, ATO and PHEN impaired performance on short ITI trials and decreased impulsivity, thus mimicking the behavioural profile of LI rats. The effects of ATO were greater on MI rats and LI rats.

conclusionsThese findings indicate that impulsivity can be advantageous when rapid focusing and actions are required, an effect that may depend on increased dopamine neurotransmission. Conversely, activation of the noradrenergic system, with ATO and PHEN, led to a general inhibition of responding.

Indexed as

Attention Deficit Disorder with HyperactivityAmphetamineAnimalsChoice BehaviorImpulsive BehaviorRatsReaction TimeAmphetamineAmphetamineAtipamezoleAtomoxetineImpulsivityMethylphenidatePhenylephrine

Identifiers

PMID34104987
PMCPMC8373759
OpenAlexW3167898345

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.