ArticleImmunology1988
Platelet-activating factor induces eosinophil peroxidase release from purified human eosinophils.
Article in Immunology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 72 citations in OpenAlex.
- The diverse effects of mast cell mediators.Clinical reviews in allergy & immunology · 2002Review
- Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation.The Biochemical journal · 1995Article
- Platelet-activating factor: an inflammatory mediator in the acute phase of allergic conjunctivitis in a guinea-pig model.Mediators of inflammation · 1995Article
- Platelet-activating factor (PAF) and the development of chronic subdural haematoma.Acta neurochirurgica · 1994Article
- Regulation of human eosinophil degranulation and activation by endogenous phospholipase A2.The Journal of clinical investigation · 1993Article
- Article
- Role for platelet-activating factor in asthma.Lipids · 1991Review
- Tumor necrosis factor alpha/cachectin stimulates eosinophil oxidant production and toxicity towards human endothelium.The Journal of experimental medicine · 1990Article
- The role of eosinophils in asthma.Lung · 1990Review
- The role of platelet activating factor in allergic respiratory disease.British journal of clinical pharmacology · 1990Review
- Density heterogeneity of eosinophil leucocytes: induction of hypodense eosinophils by platelet-activating factor.Immunology · 1989Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The degranulation response of purified human eosinophils to platelet-activating factor (PAF) has been studied. PAF induced release of eosinophil peroxidase (EPO) and beta-glucuronidase from highly purified human eosinophils with an EC50 of 0.9 nM. The order of release was comparable with that induced by phorbol myristate acetate (PMA). The new specific PAF antagonist 3-[4-(2-chlorophenyl)-9-methyl-H-thieno[3,2-f] [1,2,4]triazolo-[4,3a][1,4]-diazepin-2-yl](4-morpholinyl)- 1-propane-one (WEB 2086) inhibited the PAF-induced enzyme release by human eosinophils in a dose-dependent manner. The viability of eosinophils were unaffected both by PAF and WEB 2086. The results suggest that PAF may amplify allergic and inflammatory reactions by release of preformed proteins from eosinophil granules.
Indexed as
Identifiers
3410498PMC1385073W69125061What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.