Evidence map›Paper›PMID 34104867›Full record

Observational studyJNCI cancer spectrum2021

Race, Income, and Survival in Stage III Colon Cancer: CALGB 89803 (Alliance).

Seohyuk Lee, Sui Zhang, Chao Ma, Fang-Shu Ou, Eric G Wolfe, Shuji Ogino, Donna Niedzwiecki, Leonard B Saltz, Robert J Mayer, Rex B Mowat and 11 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in JNCI cancer spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 15 institutions in 2 countries.

Seohyuk LeeYale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3023-1304
Sui ZhangDepartment of Medical Oncology, Dana-Farber/Partners CancerCare, Boston, MA, USA.
Chao MaDepartment of Medical Oncology, Dana-Farber/Partners CancerCare, Boston, MA, USA.
Fang-Shu OuAlliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-1267-8735
Eric G WolfeAlliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN, USA.
Shuji OginoDepartment of Oncologic Pathology, Dana-Farber/Partners CancerCare and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3909-2323
Donna NiedzwieckiDepartment of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
Leonard B SaltzMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Robert J MayerDepartment of Medical Oncology, Dana-Farber/Partners CancerCare, Boston, MA, USA.
Rex B MowatToledo Community Hospital Oncology Program, Toledo, OH, USA.
Renaud WhittomHôpital du Sacré-Coeur de Montréal, Montreal, Canada.
Alexander HantelLoyola University Stritch School of Medicine, Naperville, IL, USA.
Al BensonRobert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
Daniel AtienzaVirginia Oncology Associates, Norfolk, VA, USA.
Michael MessinoSoutheast Clinical Oncology Research Consortium, Mission Hospitals, Asheville, NC, USA.
Hedy KindlerUniversity of Chicago Comprehensive Cancer Center, Chicago, IL, USA.ORCID 0000-0002-5450-842X
Alan VenookUniversity of California at San Francisco Comprehensive Cancer Center, San Francisco, CA, USA.ORCID 0000-0001-9749-6548
Cary P GrossYale School of Medicine, Department of Internal Medicine, New Haven, CT, USA.
Melinda L IrwinYale School of Public Health, New Haven, CT, USA.
Jeffrey A MeyerhardtDepartment of Medical Oncology, Dana-Farber/Partners CancerCare, Boston, MA, USA.
Charles S FuchsYale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-1582-9842
CancerCare · USYale University · USMayo Clinic · USBroad Institute · USCommunity Hospital · USDuke University · USHôpital du Sacré-Cœur de Montréal · CALoyola University Chicago · USMemorial Sloan Kettering Cancer Center · USNorthwestern University · USSoutheast Clinical Oncology Research Consortium · USUCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of Chicago · USVirginia Oncology Associates · USYale Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
ECOG-ACRIN NCORP Research Base - TMISTUG1CA189828 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$199.7M
Member Site CoreU10CA180821 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Evanthia Galanis · 2014 to 2026
$177.3M
Project-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer · 2014 to 2026
$167.6M
SWOG Network Group Operations Center of the NCTNU10CA180888 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PRIMO N. LARA · 2014 to 2026
$152.1M
Statistics CoreU10CA180882 · NCI · MAYO CLINIC ROCHESTER · PI Sumithra Jay Mandrekar · 2014 to 2026
$115.0M
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
Southeast Clinical Oncology Research Consortium, Inc. (SCOR)UG1CA189858 · NCI · SOUTHEAST CLINICAL ONCOL RES CONSORTIUM · PI Judith O Hopkins, William J Irvin · 2014 to 2026
$38.8M
THE ALLIANCE NCTN BIOREPOSITORY AND BIOSPECIMEN RESOURCEU24CA196171 · NCI · WASHINGTON UNIVERSITY · PI Mine Cicek, Wendy Frankel · 2015 to 2026
$35.0M
Tissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI BASS, ADAM JOEL · 2007 to 2023
$33.2M
Network Lead Academic Participating Site: Memorial Sloan Kettering Cancer CenterUG1CA233290 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CAROL AGHAJANIAN, Darren Feldman · 2019 to 2026
$10.2M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016359NCI NIH HHS P50 CA127003NCI NIH HHS R01 CA118553NCI NIH HHS R01 CA149222NCI NIH HHS R01 CA169141NCI NIH HHS R35 CA197735NCI NIH HHS U10 CA138561NCI NIH HHS U10 CA180791NCI NIH HHS U10 CA180820NCI NIH HHS U10 CA180821NCI NIH HHS U10 CA180867NCI NIH HHS U10 CA180882NCI NIH HHS U10 CA180888NCI NIH HHS U24 CA196171NCI NIH HHS UG1 CA189828NCI NIH HHS UG1 CA189858NCI NIH HHS UG1 CA189974NCI NIH HHS UG1 CA233180NCI NIH HHS UG1 CA233290NCI NIH HHS UG1 CA233320NCI NIH HHS UG1 CA233327NCI NIH HHS UG1 CA233337
6 · The paper itself

Abstract

Background: Disparities in colon cancer outcomes have been reported across race and socioeconomic status, which may reflect, in part, access to care. We sought to assess the influences of race and median household income (MHI) on outcomes among colon cancer patients with similar access to care. Methods: We conducted a prospective, observational study of 1206 stage III colon cancer patients enrolled in the CALGB 89803 randomized adjuvant chemotherapy trial. Race was self-reported by 1116 White and 90 Black patients at study enrollment; MHI was determined by matching 973 patients' home zip codes with publicly available US Census 2000 data. Multivariate analyses were adjusted for baseline sociodemographic, clinical, dietary, and lifestyle factors. All statistical tests were 2-sided. Results: Over a median follow-up of 7.7 years, the adjusted hazard ratios for Blacks (compared with Whites) were 0.94 (95% confidence interval [CI] = 0.66 to 1.35, Conclusions: In this study of patients with similar health-care access, no statistically significant differences in outcomes were found by race or MHI. The substantial gaps in outcomes previously observed by race and MHI may not be rooted in differences in tumor biology but rather in access to quality care.

Indexed as

Black PeopleIncomeWhite PeopleAgedChemotherapy, AdjuvantColonic NeoplasmsConfidence IntervalsDietDisease-Free SurvivalFemaleHealth Services AccessibilityHumansLife StyleMaleMiddle AgedMultivariate Analysis

Identifiers

PMID34104867
PMCPMC8178799
OpenAlexW3155739036

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.