Evidence map›Paper›PMID 34104846›Full record

ReviewAPL bioengineering2021

Surface engineering at the nanoscale: A way forward to improve coronary stent efficacy.

Aleena Mary Cherian, Shantikumar V Nair, Vijayakumar Maniyal, Deepthy Menon

Abstract readReview
In one paragraph

Review in APL bioengineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Coatings for Cardiovascular Stents-An Up-to-Date Review.International journal of molecular sciences · 2024
    Review
  7. Review
  8. Review
  9. Drug-Eluting Stents: Technical and Clinical Progress.Biomimetics (Basel, Switzerland) · 2023
    Review
  10. Hypersensitivity and in-stent restenosis in coronary stent materials.Frontiers in bioengineering and biotechnology · 2022
    Review
  11. Applying Principles of Regenerative Medicine to Vascular Stent Development.Frontiers in bioengineering and biotechnology · 2022
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aleena Mary CherianAmrita Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Ponekkara P.O. Cochin 682041, Kerala, India.ORCID https://orcid.org/0000-0002-5102-9116
Shantikumar V NairAmrita Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Ponekkara P.O. Cochin 682041, Kerala, India.ORCID https://orcid.org/0000-0002-2648-1813
Vijayakumar ManiyalDepartment of Cardiology, Amrita Institute of Medical Science and Research Centre, Amrita Vishwa Vidyapeetham, Ponekkara P.O. Cochin 682041, Kerala, India.
Deepthy MenonAmrita Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Ponekkara P.O. Cochin 682041, Kerala, India.ORCID https://orcid.org/0000-0003-2772-2276

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary in-stent restenosis and late stent thrombosis are the two major inadequacies of vascular stents that limit its long-term efficacy. Although restenosis has been successfully inhibited through the use of the current clinical drug-eluting stent which releases antiproliferative drugs, problems of late-stent thrombosis remain a concern due to polymer hypersensitivity and delayed re-endothelialization. Thus, the field of coronary stenting demands devices having enhanced compatibility and effectiveness to endothelial cells. Nanotechnology allows for efficient modulation of surface roughness, chemistry, feature size, and drug/biologics loading, to attain the desired biological response. Hence, surface topographical modification at the nanoscale is a plausible strategy to improve stent performance by utilizing novel design schemes that incorporate nanofeatures via the use of nanostructures, particles, or fibers, with or without the use of drugs/biologics. The main intent of this review is to deliberate on the impact of nanotechnology approaches for stent design and development and the recent advancements in this field on vascular stent performance.

Identifiers

PMID34104846
PMCPMC8172248

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.