ArticleBioMed research international2021
High Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Are Associated with Poor Survival in Patients with Hemodialysis.
Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between platelet-lymphocyte ratio and the risk of all-cause mortality in chronic kidney disease: a systematic review and meta-analysis.International urology and nephrology · 2022Pooled it
- A Critical Reassessment of Inflammatory and Nutritional Indices (PNI, GNRI, SII, NLR, PLR) for Predicting Arteriovenous Fistula Maturation and Long-Term Patency: A 945-Patient Cohort.Journal of clinical medicine · 2026Article
- Neutrophil-to-lymphocyte ratio as a harbinger of peritonitis in peritoneal dialysis: a case-control study.Frontiers in medicine · 2026Article
- Association of neutrophil-lymphocyte ratio with cardiovascular and all-cause mortality in patients receiving chronic hemodialysis: Systematic review and meta-analysis.World journal of methodology · 2025Article
- Article
- Assessing the Impact of Inflammation on Erythropoietin Resistance in Hemodialysis: The Role of the NLR.Journal of clinical medicine · 2025Article
- Inflammatory and nutritional indices for overall survival in Hemodialysis patients: a multicenter cohort study.BMC nephrology · 2025Article
- Prognostic impact of neutrophil-to-lymphocyte ratio and vascular access in patients on chronic hemodialysis.Journal of nephrology · 2025Article
- Neutrophil-Lymphocyte Ratio May be Used as a Biomarker for Predicting Progression of Barrett's Esophagus to Esophageal Adenocarcinoma: A Retrospective Cohort Study.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Progress in the application of novel inflammatory indicators in chronic kidney disease.Frontiers in medicine · 2025Review
- Hematological Biomarkers in Predicting Progression and Complications of Chronic Kidney Disease Among Adult Patients.Advances in hematology · 2025Article
- The Importance of Biochemical Parameters, Immunonutritional Status, and Social Support for Quality of Life in Chronic Hemodialysis Patients.Medicina (Kaunas, Lithuania) · 2024Article
- COVID-19 increases mortality in hemodialysis patients: exploring links with inflammation and telomere attrition.Molecular biology reports · 2024Article
- Hemogram-Derived Inflammatory Markers in Cats with Chronic Kidney Disease.Animals : an open access journal from MDPI · 2024Article
- Association between serum 25-hydroxyvitamin D level and inflammatory markers in hemodialysis-treated patients.Immunity, inflammation and disease · 2024Article
- Relationship between Compound α-Ketoacid and Microinflammation in Patients with Chronic Kidney Disease.Current pharmaceutical design · 2024Review
- Serum ferritin and neutrophil-to-lymphocyte ratio predict all-cause mortality in patients receiving maintenance hemodialysis: a prospective study.Frontiers in molecular biosciences · 2024Article
- Utility of pre-chemoradiotherapy Pan-Immune-Inflammation-Value for predicting the osteoradionecrosis rates in locally advanced nasopharyngeal cancers.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023Article
- Utility of a modified Controlling Nutritional Status score in mortality risk assessment of patients on hemodialysis.International urology and nephrology · 2023Article
- Relationship between immune nutrition index and all-cause and cause-specific mortality in U.S. adults with chronic kidney disease.Frontiers in nutrition · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are markers for systemic inflammation condition. Although NLR has emerged as a risk factor for poor survival in end-stage renal disease (ESRD) patients, the relationship between PLR and mortality is still unknown. We aimed to explore the interaction of NLR and PLR in predicting mortality in hemodialysis (HD) patients.
methodWe enrolled 360 HD patients for a 71-month follow-up. The endpoint was all-cause and cardiovascular (CV) mortality. Pearson correlation analysis was conducted to evaluate the relationship between factors and NLR or PLR. Kaplan-Meier curves and Cox proportional analysis were used to assess the prognostic value of NLR and PLR.
resultsNLR was positively correlated with neutrophil and negatively correlated with lymphocyte, hemoglobin, and serum albumin. PLR was positively correlated with neutrophil and platelet and negatively correlated with lymphocyte and hemoglobin. In multivariate Cox regression, a higher NLR level was independently associated with all-cause mortality (OR 2.011, 95% CI 1.082-3.74,
conclusionNLR and PLR are cheap and reliable biomarkers for all-cause and CV mortality to predict survival in HD patients.
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