Evidence map›Paper›PMID 34104416›Full record

ArticlePulmonary circulation

Clinical profile and management of patients with acute pulmonary thromboembolism - a single centre, large observational study from India.

Thoddi Ramamurthy Muralidharan, Sankaran Ramesh, Balakrishnan Vinod Kumar, Aditya V Ruia, Mohan Kumar, Akshaya Gopalakrishnan, Gurpreet S Johal, Amit Hooda, Rohit Malhotra, Reza Masoomi and 11 more

Abstract read
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Thoddi Ramamurthy MuralidharanDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.
Sankaran RameshDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.
Balakrishnan Vinod KumarDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.ORCID https://orcid.org/0000-0001-9949-4271
Aditya V RuiaDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.ORCID https://orcid.org/0000-0002-3169-1989
Mohan KumarDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.
Akshaya GopalakrishnanDepartment of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, NY, USA.
Gurpreet S JohalDivision of Interventional Cardiology, Mount Sinai School of Medicine, New York, NY, USA.
Amit HoodaDivision of Interventional Cardiology, Mount Sinai School of Medicine, New York, NY, USA.
Rohit MalhotraDivision of Interventional Cardiology, Mount Sinai School of Medicine, New York, NY, USA.
Reza MasoomiDivision of Interventional Cardiology, Mount Sinai School of Medicine, New York, NY, USA.
Mahalakshmi RamadossFaculty of Clinical Research, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.
Vinodhini SubramanianDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.
Maria J KalsinghConsultant National Health Mission, Chennai, India.
Panchanatham ManokarDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.
Jebaraj RathinasamyDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.
Shanmugasundram SadhanandhamDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.
Jayanthy V BalasubramaniyanDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.
Preetam KrishnamurthyDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.
Jayanthy S MurthyDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.
Sadagopan ThanikachalamDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.
Nagendra Boopathy SenguttuvanDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.ORCID https://orcid.org/0000-0003-4979-596X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute pulmonary thromboembolism is associated with high mortality, similar to that of myocardial infarction and stroke. We studied the clinical presentation and management of pulmonary thromboembolism in the Indian population. An analysis of 140 patients who presented with acute pulmonary thromboembolism at a large volume center in India from June 2015 through December 2018 was performed. The mean age of our study population was 50 years with 59% being male. Comorbidities including deep vein thrombosis, diabetes mellitus, hypertension, and chronic obstructive pulmonary disease were present in 52.9%, 40%, 35.7% and 7.14% of patients, respectively. Out of 140 patients, 40 (28.6%) patients had massive pulmonary thromboembolism, 36 (25.7%) sub-massive pulmonary thromboembolism, and 64 (45.7%) had low-risk pulmonary thromboembolism. Overall, in-hospital mortality was 25.7%. Multivariate regression analysis found chronic kidney disease and pulmonary thromboembolism severity to be the only independent risk factors. Thrombolysis was performed in 62.5% of patients with a massive pulmonary thromboembolism and 63.9% of patients with a sub-massive pulmonary thromboembolism. In the massive pulmonary thromboembolism group, patients receiving thrombolytic therapy had lower mortality compared with patients who did not receive therapy (

Indexed as

acute cor-pulmonaleacute pulmonary embolismshockthrombolysis

Identifiers

PMID34104416
PMCPMC8164559

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.