ArticleTherapeutic advances in psychopharmacology2021
Trends in benzodiazepine receptor agonists use and associated factors in the Belgian general older population: analysis of the Belgian health interview survey data.
Article in Therapeutic advances in psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Barriers and enablers for deprescribing benzodiazepine receptor agonists in older adults: a systematic review of qualitative and quantitative studies using the theoretical domains framework.Implementation science : IS · 2022Pooled it
- Factors Associated With Concurrent Benzodiazepine and Opioid Use Following Total Hip and Knee Arthroplasty: A Nationwide Cohort Study.Pharmacoepidemiology and drug safety · 2026Article
- Epidemiological Assessment of Benzodiazepine Dependence via Pharmacist-Led EMR Review in Pain and Palliative Care Institution.Pharmacy (Basel, Switzerland) · 2026Article
- 10-year trends in benzodiazepine, opioid, and concurrent use in hip and knee arthroplasty: a nationwide cohort study from the Netherlands.Acta orthopaedica · 2025Article
- Protocol to evaluate the feasibility of the D-PRESCRIBE intervention adapted to the Belgian community setting (END-IT CS study).BMJ open · 2025Article
- Article
- Total Joint Arthroplasty and Sleep: The State of the Evidence.Arthroplasty today · 2024Article
- Clinical Spectrum and Trajectory of Innovative Therapeutic Interventions for Insomnia: A Perspective.Aging and disease · 2023Article
- The impact of a pharmacist intervention on post-discharge hypnotic drug discontinuation in geriatric inpatients: a before-after study.BMC geriatrics · 2023Article
- "At the time I only wanted to relieve stress": Exploring motivation for behaviour change in long-term hypnotic users.Heliyon · 2023Article
- Trends in the use of benzodiazepine receptor agonists among working-age adults in Belgium from 2004 to 2018.Frontiers in public health · 2023Article
- A Need for Benzodiazepine Deprescribing in the COVID-19 Pandemic: A Cohort Study.Pharmacy (Basel, Switzerland) · 2022Article
- Evolution of benzodiazepine receptor agonist prescriptions in general practice: A registry-based study.Frontiers in public health · 2022Article
- Development of a 3D-Printed Dosing Platform to Aid in Zolpidem Withdrawal Therapy.Pharmaceutics · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBenzodiazepine receptor agonists (BZRA), which include benzodiazepines and z-drugs, are commonly prescribed for insomnia and anxiety in older adults, and used often long term. Yet, the risk-benefit ratio of BZRA use in older adults may be unfavorable and many recommendations suggest avoidance or a maximal treatment duration of 4 weeks. The aim of this study was to describe trends of BZRA use in older adults and associated factors.
methodsUsing data from the Belgian Health Interview Survey in 2004 (
resultsOverall, standardized prevalence of BZRA use decreased significantly between 2004 and 2013 [22% to 18%, prevalence difference (95% confidence interval, CI): -4.0% (-6.8; -1.3)]. Factors associated with BZRA use in multivariable analysis included female gender [adjusted odds ratio (aOR) (95%CI) : 1.62 (1.14; 2.29)], poor mental health [aOR (95%CI): 1.73 (1.13-2.63)] a fall in the past 12 months [aOR (95%CI): 1.52 (1.02; 2.26), reporting a sleeping disorder [aOR (95%CI): 1.92 (1.35; 2.72)], polypharmacy [aOR (95%CI): 2.51 (1.75; 3.60)], and trazodone use [aOR (95%CI): 4.05 (1.64; 10.21)].
conclusionDespite an encouraging decline observed from 2004 to 2013, BZRA use remained highly prevalent in Belgian older adults. Promotion of alternatives to BZRA in treatment of sleeping problems need to be continued. Among BZRA older users, women, the oldest (⩾85 years) and high-risk subgroups should be targeted in deprescribing interventions.
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