Evidence map›Paper›PMID 34104378›Full record

ArticleTherapeutic advances in chronic disease2021

Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience.

Laila M Sherief, Elhamy R Abd El-Khalek, Ibrahim A Libda, Osama A Gaber, Naglaa M Kamal, Basma K Soliman, Wesam A Mokhtar, Ghada A Mokhtar, Hosam E Salah, Gehad M Kamar and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in chronic disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Laila M SheriefFaculty of Medicine, Zagazig University, Zagazig, Egypt.ORCID https://orcid.org/0000-0003-2088-4213
Elhamy R Abd El-KhalekPediatric Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ibrahim A LibdaRadiodiagnosis Department, Faculty of medicine, Zagazig University, Zagazig, Egypt.
Osama A GaberMedical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Naglaa M KamalPediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-8535-3838
Basma K SolimanRadiodiagnosis Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Wesam A MokhtarPediatric Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ghada A MokhtarMedical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Hosam E SalahClinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Gehad M KamarMinistry of Health Hospital, Dakahleya, Egypt.
Marwa ZakariaPediatric Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Zagazig University · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn increased risk of cardiovascular complications is reported in survivors of childhood acute lymphoblastic leukemia (ALL). Early identification of impaired vascular health may allow for early interventions to improve outcomes.

aimThe study was conducted to assess the endothelial dysfunction in ALL survivors using a new marker, serum endocan, and measurement of the mean common carotid arteries intima media thickness (cIMT).

methodsA case-control study was conducted on 100 childhood ALL survivors (aged 6-18 years), with 80 healthy age and sex-matched children as a control group. Lipid profile, hepatitis markers, and serum ferritin where measured, in addition to the measurement of serum endocan. and cIMT by B-mode high-resolution ultrasonography for all study participants.

resultsTriglycerides, total cholesterol, post prandial glucose, and serum ferritin were significantly higher in ALL survivors than controls (

conclusionsThe survivors of childhood ALL demonstrated an elevated level of serum endocan and increased cIMT. These can be used as predictors of endothelial dysfunction, and, as a consequence, the risk of developing premature atherosclerosis.

Indexed as

acute lymphoblastic leukemiacarotid artery intima media thicknesschildhoodendocanendothelial dysfunctionsurvivors

Identifiers

PMID34104378
PMCPMC8155763
OpenAlexW3165382969

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.